Compare Viread vs. Vemlidy

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus.

Viread (tenofovir) is a first-line choice to be used in combination with other medications to treat HIV. Viread (tenofovir) is also a first-line choice in treating HBV.

Treats hepatitis B virus (HBV) infections.

Vemlidy (tenofovir alafenamide) decreases liver damage from hepatitis B virus (HBV) and has minimal side effects, but doesn't cure the infection.

  • Can be used with other medications to prevent HIV infection after an exposure.
  • Taken only once daily, with or without food.
  • There are newer formulations of Viread (tenofovir) available that are safer on your kidneys.
  • If tablets are hard for you to swallow, Viread (tenofovir) is available in a powder that's mixed with soft foods.
  • Vemlidy (tenofovir alafenamide) is a first-choice medicine to treat hepatitis B.
  • Conveniently taken once daily.
  • Compared to Truvada and Viread (tenofovir disoproxil fumarate), Vemlidy (tenofovir alafenamide) is safer for your kidneys and bones.
  • Viread (tenofovir) can't be used on its own to treat HIV infection.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Might worsen hepatitis B infections if you suddenly stop taking it.
  • Might not be the best choice for people with severe kidney damage.
  • There's not enough evidence to show that Vemlidy (tenofovir alafenamide) can be used safely in children ages 18 or younger.
Used for
  • Hepatitis B treatment
Dosage forms
  • Pill
  • Powder
  • Pill
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Side effects
1possible side effects
  • Nausea
See more detailed side effects
6possible side effects
  • Headache
  • Stomach pain
  • Tiredness
  • Cough
  • Nausea
  • Back pain
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Cannot be used to treat Hepatitis B Virus (HBV)
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental illness
  • Decreased bone mineral density
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Concurrent use of other drugs known to harm kidneys
  • Hypersensitivity (allergic) reactions
    • Prior severe allergic reaction to Viread (tenofovir) or any of its individual drug components.
See more detailed risks and warnings
  • Worsening of hepatitis B infection
    • Stopping Vemlidy (tenofovir alafenamide)
  • Hepatitis B and HIV co-infection
    • HIV infection
  • Kidney damage
    • Poor kidney function
    • Taking other medicines that can damage the kidneys
  • Buildup of acid in the blood and swollen, fatty liver
  • Lowered bone mineral density
    • Long-term use of Vemlidy (tenofovir alafenamide)
    • Use of other medications that result in loss of electrolytes or minerals
See more detailed risks and warnings