Compare Vivelle-Dot vs. Divigel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves menopausal symptoms.

Vivelle-Dot (Estradiol patch) is an estrogen patch that may be easier and more convenient to use than the pill or gel form.

Relieves hot flashes due to menopause.

Divigel (Estradiol gel) is an easy to use medicine that comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements.

Upsides
  • Good choice if you want to avoid daily dosing of the pill or gel form.
  • Available in wider variety of strengths compared to other estrogen patches.
  • Replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Good for people who don't want to or can't take daily pills.
  • Can take the easy to use, pre-measured packets anywhere.
  • Divigel (Estradiol gel) has fewer side effects than pills since there are lower amounts of estrogen in gels.
  • In studies, many women on the lowest dose started to feel better about a month after starting the medicine. People using the highest doses felt better in just 2 weeks.
Downsides
  • Other estrogen patches are dosed once weekly and may be more convenient than Vivelle-Dot (Estradiol patch).
  • Patches can fall off.
  • Estrogen therapy is associated with serious risks for uterine cancer, breast cancer, and blood clots. Don't start treatment until you have had a thorough discussion of the risks and benefits with your doctor.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
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Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Prevention of osteoporosis in menopausal women
Dosage forms
  • Patch
  • Gel
Price
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Reviews
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Side effects
20possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
  • Neck pain
    5%
  • Limb pain
    5%
  • Nasal congestion
    5%
  • Joint pain
    4%
  • Depression
    3%
  • Constipation
    2%
  • Flu-like symptoms
    2%
  • Sinus headache
    2%
  • Anxiety
    2%
  • Trouble sleeping
    2%
See more detailed side effects
5possible side effects
  • Breast pain
    6%
  • Unusual vaginal bleeding
    6%
  • Common cold
    4%
  • Lung infection
    2%
  • Yeast infection
    2%
See more detailed side effects
Risks and risk factors
  • Uterine cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings