Compare Vivelle-Dot vs. Estrace vaginal cream

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves menopausal symptoms.

Vivelle-Dot (Estradiol patch) is an estrogen patch that may be easier and more convenient to use than the pill or gel form.

Relieves vaginal dryness due to menopause.

Estrace vaginal cream (Estradiol vaginal cream) works well to treat menopausal symptoms localized to the vagina.

3.9/ 5 average rating with 15 reviewsforEstrace vaginal cream
Upsides
  • Good choice if you want to avoid daily dosing of the pill or gel form.
  • Available in wider variety of strengths compared to other estrogen patches.
  • Side-effects are limited compared to estrogen pill since application is localized to the vagina only.
Downsides
  • Other estrogen patches are dosed once weekly and may be more convenient than Vivelle-Dot (Estradiol patch).
  • Patches can fall off.
  • Estrogen therapy is associated with serious risks for uterine cancer, breast cancer, and blood clots. Don't start treatment until you have had a thorough discussion of the risks and benefits with your doctor.
  • Method of application can be difficult or uncomfortable compared to a pill that is taken by mouth.
  • It is not effective for hot flashes.
  • The cream is not compatible with certain birth control methods. It can weaken latex (rubber) condoms, cervical caps, and diaphrams so avoid use within 72 hours after a dose.
  • The applicator can be source of infection if not kept clean.
  • Available as a brand name product only.
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Used for
  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen
  • Prevention of osteoporosis in menopausal women
  • Vaginal dryness and inflammation
Dosage forms
  • Patch
  • Cream
Price
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Reviews
Not enough review data.Leave a review
15 reviews so far
60%
saidit'sworth it
73%
saiditworked well
47%
saidit'sa big hassle

Have you used Estrace vaginal cream (Estradiol vaginal cream)?

Leave a review
Side effects
20possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
  • Neck pain
    5%
  • Limb pain
    5%
  • Nasal congestion
    5%
  • Joint pain
    4%
  • Depression
    3%
  • Constipation
    2%
  • Flu-like symptoms
    2%
  • Sinus headache
    2%
  • Anxiety
    2%
  • Trouble sleeping
    2%
See more detailed side effects
The Estrace vaginal cream (Estradiol vaginal cream) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Uterine cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Inflammation of pancreas
    • High levels of triglycerides
See more detailed risks and warnings