Compare Vyvanse vs. Intuniv

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Intuniv (guanfacine ER)

Prescription only
Helps you focus and stay alert.

Vyvanse (lisdexamfetamine) is a first-choice treatment for attention-deficit/hyperactivity disorder, but it can be expensive since it's only available as a brand name product.

3.7/ 5 average rating with 491 reviewsforVyvanse
Helps you focus your thoughts.

Intuniv (guanfacine ER) is an option for ADHD patients who cannot take stimulants.

Upsides
  • Vyvanse (lisdexamfetamine) is a first-choice medication to treat attention-deficit/hyperactivity disorder (ADHD).
  • It is usually dosed once a day, so parents don't need to send the medication with their children to school.
  • Can take the capsule as a whole or mix the contents with water, orange juice, or yogurt.
  • Available as a chewable pill form.
  • Not a stimulant and is an option for people who cannot take stimulants.
  • Can be used either alone or with other stimulant medications.
  • Available in generic.
Downsides
  • Need to take Vyvanse (lisdexamfetamine) in the morning, otherwise it can cause difficulty sleeping at night.
  • Vyvanse (lisdexamfetamine) is not available as a generic medication, so it is expensive.
  • This medicine has the potential for abuse and dependence.
  • Can cause serious side effects for the heart.
  • Can also slow growth in children and cause weight loss.
  • Intuniv (guanfacine ER) can cause changes in your blood pressure so it will be important to watch your blood pressure regularly.
  • May cause drowsiness, dizziness, and headaches especially at higher doses.
  • It can make you feel more irritable or anxious. Talk to your doctor if it bothers you.
  • Not recommended for people over 65 years old.
  • It may cause drowsiness, especially when you first start taking Intuniv (guanfacine ER) or with dose increases, so do not drive until you know how Intuniv (guanfacine ER) affects you.
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Used for
  • ADHD
  • Tourette syndrome (children and adolescents)
Dosage forms
  • Pill
  • Extended release
Price
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Reviews
491 reviews so far
67%
saidit'sworth it
49%
saiditworked well
17%
saidit'sa big hassle

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Side effects
15possible side effects
  • Decreased appetite
    27%
  • Difficulty sleeping
    27%
  • Dry mouth
    26%
  • Diarrhea
    7%
  • Nausea
    7%
  • Anxiety
    6%
  • Loss of appetite
    5%
  • Feeling jittery
    4%
  • Agitation
    3%
  • Increased blood pressure
    3%
  • Sweating
    3%
  • Restlessness
    3%
  • Difficulty breathing
    2%
  • Increased heart rate
    2%
  • Tremor
    2%
See more detailed side effects
11possible side effects
  • Headache
    27%
  • Fatigue
    22%
  • Dizziness
    16%
  • Loss of appetite
    15%
  • Stomach pain
    12%
  • Irritability
    7%
  • Anxiety
    5%
  • Rash
    3%
  • Constipation
    3%
  • Weight gain
    3%
  • Itchiness
    2%
See more detailed side effects
Risks and risk factors
  • High blood pressure
    • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting Vyvanse (lisdexamfetamine)
  • Abuse and dependence
    • History of drug abuse
  • Serious or life-threatening cardiovascular events
    • History of heart problems
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of bipolar disorder
  • Long-term growth suppression
    • Children ages 6 to 12
See more detailed risks and warnings
  • Fainting
    • High blood pressure
    • Heartrate problems
  • Sleepiness
  • Increased blood pressure and heart rate
    • Stopping Intuniv (guanfacine ER) suddenly.
  • Heart problems
    • History of heart problem
See more detailed risks and warnings