Compare Wellbutrin vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Wellbutrin (Bupropion)

Prescription only

Pristiq (desvenlafaxine)

Prescription only
Improves mood.

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

3.4/ 5 average rating with 1164 reviewsforWellbutrin
Improves mood.

Pristiq (desvenlafaxine) is an effective medicine for treating depression, but it is more expensive than many other medicines that work just like it.

3.5/ 5 average rating with 196 reviewsforPristiq
Upsides
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • You only need to take Pristiq (desvenlafaxine) once a day.
  • May be taken with or without food.
  • Less sedating than other anti-depressants.
Downsides
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Like most anti-depressants, full effect on mood takes up to 12 weeks.
  • Can increase the risk of suicidal thoughts and/or behavior in yound adults 24 years and younger.
  • Can affect your sex drive and ability to get an erection.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Extended-release pill
Price
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Reviews
1164 reviews so far
60%
saidit'sworth it
40%
saiditworked well
13%
saidit'sa big hassle

Have you used Wellbutrin (Bupropion)?

Leave a review
196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle

Have you used Pristiq (desvenlafaxine)?

Leave a review
Side effects
29possible side effects
  • Agitation
    32%
  • Dry mouth
    28%
  • Constipation
    26%
  • Headache/migraine
    26%
  • Nausea/vomiting
    23%
  • Dizziness
    22%
  • Excessive sweating
    22%
  • Tremor
    21%
  • Sleepiness
    20%
  • Insomnia
    19%
  • Blurred vision
    15%
  • Tachycardia
    11%
  • Confusion
    8%
  • Rash
    8%
  • Hostility
    6%
  • Auditory disturbance
    5%
  • Menstrual complaints
    5%
  • Cardiac arrhythmias
    5%
  • Impaired sleep quality
    4%
  • Sensory disturbance
    4%
  • Appetite increase
    4%
  • Palpitations
    4%
  • Hypertension
    4%
  • Impotence
    3%
  • Anxiety
    3%
  • Decreased libido
    3%
  • Gustatory disturbance
    3%
  • Dyspepsia
    3%
  • Hypotension
    3%
See more detailed side effects
17possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Excessive sweating
    10%
  • Constipation
    9%
  • Inability to sleep
    9%
  • Tiredness
    7%
  • Decreased appetite
    5%
  • Drowsiness
    4%
  • Vomiting
    3%
  • Anxiety
    3%
  • Blurry vision
    3%
  • Tremor
    2%
  • Abnormal dreams
    2%
  • Dilated pupils
    2%
  • Vertigo
    2%
  • Ringing in ears
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Psychiatric effects for smoking cessation
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine
  • Seizures
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Weight loss
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Taking other medicines that also increase serotonin activity: Antidepressants (SSRIs, SNRIs, TCAs)
    • lithium
    • tramadol
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
  • Increased blood pressure
    • People with a history of high blood pressure or other heart conditions
  • Increased bleeding risk
    • Taking NSAIDS, blood thinners, or aspirin
  • Low sodium levels in blood
    • Older people
    • Taking diuretics
  • Stopping Pristiq (desvenlafaxine) too quickly
    • Taking the medicine for a long time
    • Stopping Pristiq (desvenlafaxine) too quickly
See more detailed risks and warnings