Compare Xarelto vs. Eliquis

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Xarelto (rivaroxaban)

Prescription only

Eliquis (apixaban)

Prescription only
Prevents blood clots.

Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.

3.5/ 5 average rating with 22 reviewsforXarelto
Prevents blood clots.

Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.

3.8/ 5 average rating with 19 reviewsforEliquis
Upsides
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
Downsides
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
22 reviews so far
45%
saidit'sworth it
45%
saiditworked well
9%
saidit'sa big hassle

Have you used Xarelto (rivaroxaban)?

Leave a review
19 reviews so far
47%
saidit'sworth it
58%
saiditworked well
21%
saidit'sa big hassle

Have you used Eliquis (apixaban)?

Leave a review
Side effects
2possible side effects
  • Major bleeding needing transfusion
    4%
  • Bleeding in the stomach & intestines
    2%
See more detailed side effects
1possible side effects
  • Major bleed
    2%
See more detailed side effects
Risks and risk factors
  • Blood clots and stroke
    • Stopping Xarelto (rivaroxaban) too soon
    • Artificial heart valve
  • Blood clot in the spine
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
  • Unusual bleeding
    • History of bleeding problems
    • Severe high blood pressure
    • Age 65 or older
    • Drug interactions
    • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Increased side effects
    • Current kidney problems
    • Current liver problems
See more detailed risks and warnings
  • Increased risk of stroke or blood clots from early discontinuation
    • Stopping Eliquis (apixaban) prematurely
  • Paralysis in the spine
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • History of spinal surgery
    • Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), or other blood-thinners
  • Interactions with other drugs
  • Increased risk of stroke or bleeding
    • Artificial heart valve
  • Increased side effects in kidney or liver conditions
    • Current kidney problems
    • Current liver problems
See more detailed risks and warnings