Compare Xyzal vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Xyzal (Levocetirizine)

Prescription only

Zyrtec (cetirizine)

Over-the-counter
Treats allergy symptoms.

Xyzal (Levocetirizine) is good for treating allergy symptoms, but it can cause drowsiness.

4.3/ 5 average rating with 16 reviewsforXyzal
Treats allergy symptoms.

Zyrtec (cetirizine) can help you with some allergy symptoms without making you very drowsy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Upsides
  • Xyzal (Levocetirizine) is taken once a day to help with allergy symptoms.
  • Available as a generic in both liquid and tablets.
  • Can be taken with or without food.
  • Children can take lower doses of Xyzal (Levocetirizine).
  • Zyrtec (cetirizine) works to treat sneezing and runny nose, and causes less sedation compared to Benadryl.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (cetirizine) is available over the counter without a prescription. It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide relief of allergy symptoms for both kids and adults.
  • Zyrtec (cetirizine) has few drug interactions with other medicines.
  • Most people don't get any side effects from Zyrtec (cetirizine).
Downsides
  • Can cause drowsiness.
  • Don't take Xyzal (Levocetirizine) if you have poor kidney function.
  • Xyzal (Levocetirizine) is similar to Zyrtec, another allergy medication, so if you can't take Zyrtec, you won't be able to take Xyzal (Levocetirizine).
  • Although it works fast, Zyrtec (cetirizine)'s effectiveness wears off for some people over time.
  • Zyrtec (cetirizine) can make you a little more sleepy compared to Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl (diphenhydramine), are more effective for them than Zyrtec (cetirizine).
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
Price
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Reviews
16 reviews so far
88%
saidit'sworth it
88%
saiditworked well
13%
saidit'sa big hassle

Have you used Xyzal (Levocetirizine)?

Leave a review
1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

Have you used Zyrtec (cetirizine)?

Leave a review
Side effects
7possible side effects
  • Somnolence
    6%
  • Nasopharyngitis
    4%
  • Fatigue
    4%
  • Pyrexia
    4%
  • Cough
    3%
  • Dry Mouth
    2%
  • Epistaxis
    2%
See more detailed side effects
The Zyrtec (cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Increased side effects
    • Current kidney problems
  • Increased side effects
    • Age 65 or older
  • Urinary retention or blockage
    • Enlarged prostate
    • Spinal cord conditions
See more detailed risks and warnings
  • Increased side effects in the elderly
    • Age 65 or older
  • Impaired alertness
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • History of liver or kidney conditions
    • History of liver or kidney disease
See more detailed risks and warnings