Compare Zanaflex vs. Gablofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zanaflex (tizanidine)

Prescription only

Gablofen (baclofen)

Prescription only
Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

4.3/ 5 average rating with 26 reviewsforZanaflex
Works well to control muscle spasticity.

Gablofen (baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others. It is administered intrathecally by a pump connecting to your spine.

Upsides
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
  • Gablofen (baclofen) is the agent of choice for treatment of muscle spasticity.
  • Gablofen (baclofen) has fewer side effects than the oral form, since higher levels can be delivered to the spine at lower doses.
Downsides
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
  • Gablofen (baclofen) can cause sleepiness and drowsiness.
  • Stopping Gablofen (baclofen) right away can be life-threatening, so a doctor would need to help you stop it.
  • Gablofen (baclofen) has to be started in the doctor's office. You or your caregiver need to be trained on how to use the pump.
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Used for
Dosage forms
  • Pill
  • Injection
Price
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Reviews
26 reviews so far
81%
saidit'sworth it
73%
saiditworked well
19%
saidit'sa big hassle

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Side effects
17possible side effects
  • Dry mouth
    49%
  • Sleepiness
    48%
  • Weakness
    41%
  • Dizziness
    16%
  • Urinary tract infection
    10%
  • General infection
    6%
  • Liver test abnormality
    6%
  • Constipation
    4%
  • Vomiting
    3%
  • Speech disorder
    3%
  • Blurred vision
    3%
  • Urinary frequency
    3%
  • Flu syndrome
    3%
  • Involuntary muscle movement
    3%
  • Nervousness
    3%
  • Sore throat
    3%
  • Hay fever
    3%
See more detailed side effects
21possible side effects
  • Loss of muscle tone
    35%
  • Drowsiness
    19%
  • Headache
    11%
  • Convulsion
    10%
  • Urinary Retention
    8%
  • Dizziness
    8%
  • Nausea
    7%
  • Increased muscle tone
    6%
  • Vomiting
    4%
  • Slowed breathing
    4%
  • Pain
    4%
  • Itchiness
    4%
  • Increased salivation
    3%
  • Swelling of limbs
    3%
  • Back pain
    2%
  • Constipaiton
    2%
  • Diarrhea
    2%
  • Weak muscles
    2%
  • Pneumonia
    2%
  • Urination control problems
    2%
  • Inability to urinate
    2%
See more detailed side effects
Risks and risk factors
  • Liver damage
    • Taking maximum doses of Zanaflex (tizanidine)
  • Dizziness and low blood pressure
    • Age 65 years or older
    • Currently on blood pressure control medications
  • Sleepiness and driving impairment
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
  • Withdrawal side effects
    • Stopping Zanaflex (tizanidine) suddenly
See more detailed risks and warnings
  • Withdrawal symptoms
    • Stopping Gablofen (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings