Compare Zantac vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

3.7/ 5 average rating with 1062 reviewsforZantac
Relieves symptoms of indigestion and pain

Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) provides quick relief for heartburn, upset stomach, headaches, and general pain. However, you have to take it a few times a day to continue getting relief of your symptoms.

3.9/ 5 average rating with 1055 reviewsforAlka-Seltzer
Upsides
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
  • Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) is a great option if you have an upset stomach and a headache or body aches at the same time.
  • Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) works quickly to relieve symptoms.
  • Available over the counter without a prescription.
  • Also, available as generic and is fairly cheap.
Downsides
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
  • The effects of this medication don't last very long. Other medicines, like Zantac (H2 blockers) and omeprazole (proton pump inhibitors), work better and last longer.
  • Because this medicine contains aspirin, it raises the risk of bleeding, especially if you take any other blood thinning medicines.
  • People who are allergic to aspirin can't use this medication.
  • May not like the taste or fizz.
  • Kids or teenagers should not use Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) unless instructed by a doctor.
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Used for
Dosage forms
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
  • Effervescent tablet
Price
No pricing information available
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Reviews
1062 reviews so far
72%
saidit'sworth it
44%
saiditworked well
7%
saidit'sa big hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
1055 reviews so far
81%
saidit'sworth it
52%
saiditworked well
8%
saidit'sa big hassle

Have you used Alka-Seltzer (aspirin / citric acid / sodium bicarbonate)?

Leave a review
Side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
The Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Confusion
    • Aged 60 years or older
    • Kidney conditions
    • Liver conditions
  • Drug interactions
  • Acute porphyria
    • Acute Porphyria
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
See more detailed risks and warnings
  • Taking the wrong medication
    • Not reading the drug label
  • Brain damage or death from Reye's Syndrome
    • Children 18 years or younger recovering from viral infections
  • High blood sodium levels
    • Current kidney disease
    • Dialysis
    • Age 65 or older
    • Hyperparathyroidism
    • Use of other medicines that can cause kidney damage
  • May worsen heart or kidney problems
    • Congestive heart failure (CHF)
    • High blood pressure
    • Current kidney disease
    • Kidney dialysis
  • Stomach Bleeding
    • History of stomach bleeding or ulcers
    • Age 60 or older
    • Also taking other blood thinners
    • Drinking 3 or more alcoholic drinks a day
  • Harm to unborn babies
    • Pregnancy
See more detailed risks and warnings