Compare Zantac vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zantac 75 (ranitidine)

Prescription or OTC

Maalox (aluminum / magnesium / simethicone)

Over-the-counter

Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

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3.7/ 5 average rating with 1062 reviewsforZantac

Relieves heartburn and indigestion.

Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.

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3.4/ 5 average rating with 213 reviewsforMaalox

Upsides

Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
If you have trouble swallowing pills you may find the liquid product a good option.
Inexpensive with over-the-counter and generic options.
Coupons are available for the brand product - speak to your doctor or pharmacist.

Works quickly.
Inexpensive and available over-the-counter.
Is one of the first choice medications for heartburn relief if you are pregnant.

Downsides

Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.

Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.

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