Compare Zantac vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

3.7/ 5 average rating with 1062 reviewsforZantac
Relieves heartburn and indigestion.

Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.

3.4/ 5 average rating with 213 reviewsforMaalox
Upsides
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
Downsides
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
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Used for
Dosage forms
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
  • Chewable tablet
  • Liquid
Price
No pricing information available
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Reviews
1062 reviews so far
72%
saidit'sworth it
44%
saiditworked well
7%
saidit'sa big hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
213 reviews so far
69%
saidit'sworth it
30%
saiditworked well
9%
saidit'sa big hassle

Have you used Maalox (aluminum / magnesium / simethicone)?

Leave a review
Side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
The Maalox (aluminum / magnesium / simethicone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Confusion
    • Aged 60 years or older
    • Kidney conditions
    • Liver conditions
  • Drug interactions
  • Acute porphyria
    • Acute Porphyria
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
See more detailed risks and warnings
  • Long term use
  • Aluminum and magnesium overdose
    • Kidney problems
    • Taking more than the recommended daily maximum
  • Drug interactions
See more detailed risks and warnings