Compare Zarontin vs. Lamictal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zarontin (ethosuximide)

Prescription only

Lamictal (Lamotrigine)

Prescription only
Controls absence seizures.

Zarontin (ethosuximide) is a first choice medicine to treat absence seizures as it has less side effects than similar medicines. However, you can't use it for other types of seizures.

Prevents seizures and stabilizes mood.

Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

3.7/ 5 average rating with 184 reviewsforLamictal
Upsides
  • Zarontin (ethosuximide) is recommended for treating absence seizures in children because its side effects are less severe.
  • If you have other types of seizures, you can take Zarontin (ethosuximide) with your other seizure medicines.
  • Available in generic as both a pill and a liquid form.
  • Approved in children age 3 and older.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
Downsides
  • Zarontin (ethosuximide) is only recommended for absence or petit mal seizures. It can't be used to treat other types of seizures.
  • Your doctor will have to run blood tests regularly the first few weeks to make sure you're getting enough Zarontin (ethosuximide).
  • Zarontin (ethosuximide) can interact with a lot of medicines. Talk to your doctor to see if changes need to be made in your other medicines.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
Price
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Reviews
Not enough review data.Leave a review
184 reviews so far
66%
saidit'sworth it
58%
saiditworked well
18%
saidit'sa big hassle

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Side effects
The Zarontin (ethosuximide) FDA package insert doesn’t have numbers about how common side effects are.
36possible side effects
  • Dizziness
    38%
  • Headache
    28%
  • Diplopia
    28%
  • Ataxia
    22%
  • Nausea
    19%
  • Blurred vision
    16%
  • Somnolence
    14%
  • Rhinitis
    14%
  • Pharyngitis
    10%
  • Rash
    10%
  • Vomiting
    9%
  • Cough increased
    8%
  • Flu syndrome
    7%
  • Dysmenorrhea
    7%
  • Fever
    6%
  • Diarrhea
    6%
  • Incoordination
    6%
  • Insomnia
    6%
  • Abdominal pain
    5%
  • Dyspepsia
    5%
  • Constipation
    4%
  • Tremor
    4%
  • Depression
    4%
  • Anxiety
    4%
  • Vaginitis
    4%
  • Convulsion
    3%
  • Irritability
    3%
  • Speech disorder
    3%
  • Pruritus
    3%
  • Vision abnormality
    3%
  • Neck pain
    2%
  • Reaction aggravated (seizure exacerbation)
    2%
  • Anorexia
    2%
  • Arthralgia
    2%
  • Concentration disturbance
    2%
  • Amenorrhea
    2%
See more detailed side effects
Risks and risk factors
  • Changes in blood cell counts
  • Liver and kidney damage
    • History of kidney damage
    • History of liver damage
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Lupus
  • Skin allergies and rashes
  • Treats only absence seizures
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • History of depression
  • Serious skin rash
    • People also taking Depakote
    • Taking more than the prescribed dose
    • Increasing the dose too quickly
  • Serious allergic reactions
  • Blood disorders
  • Meningitis
  • Interactions with birth control pills
    • Taking birth control pills
  • Withdrawal seizures
    • Stopping Lamictal (Lamotrigine) suddenly
See more detailed risks and warnings