Compare Zegerid vs. Pepcid
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.
Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
- Most people can take Zegerid without any noticeable day-to-day side effects.
- Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
- Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
- Is inexpensive as both generic and over-the-counter options are availabe.
- Most people can take Famotidine without any noticeable day-to-day side effects.
- Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
- You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
- Available as both a generic and over-the-counter option, so it's pretty affordable.
- Few drug interactions.
- Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
- May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
- Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
- Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
- Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
- Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
- Chewable tablet
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- Severe diarrhea
- Use during hospitalization
- Bone fractures
- Long-term use of Zegerid (omeprazole and sodium bicarbonate)
- Using high doses of Zegerid (omeprazole and sodium bicarbonate)
- Drug interactions
- Chronic lung problems
- Lung problems
- Low vitamin or mineral levels
- Hiding possible cancer
- Increased side effects
- Current kidney disease
- Allergic reaction