Compare Zegerid vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves heartburn and excess stomach acid, and treats ulcers.

Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.

3.8/ 5 average rating with 74 reviewsforZegerid
Relieves heartburn and acid tummy.

Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.

3.7/ 5 average rating with 1089 reviewsforRolaids
Upsides
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
  • Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
  • Is inexpensive as both generic and over-the-counter options are availabe.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides
  • Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
  • May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
  • Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
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Used for
Dosage forms
  • Pill
  • Suspension
  • Chewable tablet
  • Liquid
Price
No pricing information available
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Reviews
74 reviews so far
72%
saidit'sworth it
55%
saiditworked well
12%
saidit'sa big hassle

Have you used Zegerid (omeprazole and sodium bicarbonate)?

Leave a review
1089 reviews so far
75%
saidit'sworth it
37%
saiditworked well
7%
saidit'sa big hassle

Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?

Leave a review
Side effects
The Zegerid (omeprazole and sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
The Rolaids (Calcium Carbonate / Magnesium Hydroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Severe diarrhea
    • Elderly
    • Use during hospitalization
  • Bone fractures
    • Long-term use of Zegerid (omeprazole and sodium bicarbonate)
    • Using high doses of Zegerid (omeprazole and sodium bicarbonate)
  • Drug interactions
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
  • Low vitamin or mineral levels
  • Lupus
See more detailed risks and warnings
  • Taking the wrong medication
  • High blood calcium
    • Current kidney disease
    • Kidney dialysis
    • Hyperparathyroid disease
    • Taking high doses of Vitamin D
  • Kidney stones
    • Previous kidney stones
See more detailed risks and warnings