Compare Zegerid vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves heartburn and excess stomach acid, and treats ulcers.

Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.

3.8/ 5 average rating with 74 reviewsforZegerid
Relieves heartburn and acid tummy.

Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.

3.7/ 5 average rating with 1089 reviewsforRolaids
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
  • Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
  • Is inexpensive as both generic and over-the-counter options are availabe.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
  • May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
  • Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
Used for
Dosage forms
  • Pill
  • Suspension
  • Chewable tablet
  • Liquid
No pricing information available
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74 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Zegerid (omeprazole and sodium bicarbonate)?

Leave a review
1089 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Rolaids (Calcium Carbonate / Magnesium Hydroxide)?

Leave a review
Side effects
The Zegerid (omeprazole and sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
The Rolaids (Calcium Carbonate / Magnesium Hydroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Severe diarrhea
    • Elderly
    • Use during hospitalization
  • Bone fractures
    • Long-term use of Zegerid (omeprazole and sodium bicarbonate)
    • Using high doses of Zegerid (omeprazole and sodium bicarbonate)
  • Drug interactions
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
  • Low vitamin or mineral levels
  • Lupus
See more detailed risks and warnings
  • Taking the wrong medication
  • High blood calcium
    • Current kidney disease
    • Kidney dialysis
    • Hyperparathyroid disease
    • Taking high doses of Vitamin D
  • Kidney stones
    • Previous kidney stones
See more detailed risks and warnings