Compare Zegerid vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves heartburn and excess stomach acid, and treats ulcers.

Zegerid (omeprazole and sodium bicarbonate) is an effective medicine for heartburn, but it's more expensive than buying omeprazole by itself.

3.8/ 5 average rating with 74 reviewsforZegerid
Relieves heartburn.

Tums (Calcium carbonate) gives quick relief for heartburn, but does not last all day. Talk to your doctor or pharmacist about other medicines if you need additional relief.

3.8/ 5 average rating with 1373 reviewsforTums
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you may only need to take it once a day.
  • Contains both a quick acting and a long acting component to help provide fast and long lasting relief.
  • Is inexpensive as both generic and over-the-counter options are availabe.
  • Tums (Calcium carbonate) is an effective, first-line medication for hearburn.
  • Tums (Calcium carbonate) starts working in seconds.
  • Has minimal side effects.
  • Available in chewable form.
  • Is inexpensive and readily available over-the-counter.
  • Coupons are available – speak to your doctor or pharmacist.
  • Zegerid (omeprazole and sodium bicarbonate) contains sodium bicarbonate which isn't good if your doctor's asked you to lower your sodium bicarbonate or if you have heart or blood pressure problems.
  • May not be the best option if you have Bartter's syndrome due to sodium bicarbonate. Speak to your doctor first.
  • Should not be used for occasional heartburns. Talk to your doctor or pharmacist about other medications if you do not have frequent heartburns.
  • Because Tums (Calcium carbonate) only lasts for 1 to 2 hours, you may need additional doses.
  • May increase calcium levels too much in people with kidney or thyroid conditions.
  • May have a chalky taste.
Used for
Dosage forms
  • Pill
  • Suspension
  • Chewable tablet
  • Liquid
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74 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Zegerid (omeprazole and sodium bicarbonate)?

Leave a review
1373 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Tums (Calcium carbonate)?

Leave a review
Side effects
The Zegerid (omeprazole and sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
The Tums (Calcium carbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Severe diarrhea
    • Elderly
    • Use during hospitalization
  • Bone fractures
    • Long-term use of Zegerid (omeprazole and sodium bicarbonate)
    • Using high doses of Zegerid (omeprazole and sodium bicarbonate)
  • Drug interactions
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
  • Low vitamin or mineral levels
  • Lupus
See more detailed risks and warnings
No information currently available