Compare Zepatier vs. Copegus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats hepatitis C.

Zepatier (elbasvir / grazoprevir) is a combination pill that treats hepatitis C genotypes 1 and 4, but it can't be used if you have moderate to severe liver disease.

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  • Zepatier (elbasvir / grazoprevir) can cure hepatitis C, which means the virus can't be detected in the blood 3 months after completing treatment.
  • If you only need to take Zepatier (elbasvir / grazoprevir), it’s just 1 pill once a day for 12 or 16 weeks.
  • Zepatier (elbasvir / grazoprevir) can be taken by people with kidney problems, even those on hemodialysis.
  • Zepatier (elbasvir / grazoprevir) usually has mild side effects.
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  • Zepatier (elbasvir / grazoprevir) doesn't work for all genotypes of hepatitis C. It should only be used for genotype 1 or 4.
  • Some people need to take Zepatier (elbasvir / grazoprevir) together with another medication called ribavirin. Ribavirin has its own set of side effects.
  • You shouldn’t take Zepatier (elbasvir / grazoprevir) if you have moderate to severe liver disease.
  • If you've ever had hepatitis B virus infection, the virus could become active again during or after treatment with Zepatier (elbasvir / grazoprevir). Before starting it, your doctor will do blood tests to check for hepatitis B virus.
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Used for
  • Hepatitis C infection genotype 1 and 4
  • Hematopoietic stem cell transplant - Respiratory syncytial virus infection Hepatitis C
  • Chronic
  • Combination therapy in interferon alfa-naive patients with compensated liver disease - HIV infection Hepatitis C
  • Chronic
  • With compensated liver disease Respiratory syncytial virus infection
  • Herpes simplex Influenza Viral hemorrhagic fever
Dosage forms
  • Pill
  • Pill
  • Liquid
  • Inhaler
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Side effects
3possible side effects
  • Nausea
  • Headache
  • Tiredness
See more detailed side effects
The Copegus (Ribavirin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Risks and warnings of ribavirin
    • Taking ribavirin with Zepatier (elbasvir / grazoprevir)
  • Abnormally high liver test
    • Female
    • Asian
    • Age 65 or older
  • Drug interactions
See more detailed risks and warnings
No information currently available