Compare Zepatier vs. Olysio

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats hepatitis C.

Zepatier (elbasvir / grazoprevir) is a combination pill that treats hepatitis C genotypes 1 and 4, but it can't be used if you have moderate to severe liver disease.

Treats hepatitis C infection.

Olysio (simeprevir) is effective in treating chronic hepatitis C, but it must be used with other antiviral medicines.

  • Zepatier (elbasvir / grazoprevir) can cure hepatitis C, which means the virus can't be detected in the blood 3 months after completing treatment.
  • If you only need to take Zepatier (elbasvir / grazoprevir), it’s just 1 pill once a day for 12 or 16 weeks.
  • Zepatier (elbasvir / grazoprevir) can be taken by people with kidney problems, even those on hemodialysis.
  • Zepatier (elbasvir / grazoprevir) usually has mild side effects.
  • Most people who take Olysio (simeprevir) together with other antiviral medicines have good results, with no signs of virus found in their blood three months later.
  • Unlike some other hepatitis C medications, you can take Olysio (simeprevir) even if you are taking an acid reflux medication.
  • Can take Olysio (simeprevir) for a shorter amount of time than other hepatitis C medications.
  • Has less side effects than some hepatitis C medications.
  • Zepatier (elbasvir / grazoprevir) doesn't work for all genotypes of hepatitis C. It should only be used for genotype 1 or 4.
  • Some people need to take Zepatier (elbasvir / grazoprevir) together with another medication called ribavirin. Ribavirin has its own set of side effects.
  • You shouldn’t take Zepatier (elbasvir / grazoprevir) if you have moderate to severe liver disease.
  • If you've ever had hepatitis B virus infection, the virus could become active again during or after treatment with Zepatier (elbasvir / grazoprevir). Before starting it, your doctor will do blood tests to check for hepatitis B virus.
  • There's no generic available, so it can be very expensive.
  • Olysio (simeprevir) should not be used alone, it must be used together with other antiviral medicines.
  • There are many interactions between Olysio (simeprevir) and other drugs and herbal supplements. Talk to your doctor or pharmacist before starting any new medications.
  • Olysio (simeprevir) can cause a rash if you're out in the sun, so you'll have to use sunblock or wear protective clothing.
  • Olysio (simeprevir) only works with one specific type of hepatitis C, unlike others that treat all 6 types.
Used for
  • Hepatitis C infection genotype 1 and 4
Dosage forms
  • Pill
  • Pill
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Side effects
3possible side effects
  • Nausea
  • Headache
  • Tiredness
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5possible side effects
  • Rash
  • Itchy skin
  • Nausea
  • Muscle pain
  • Trouble breathing
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Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Risks and warnings of ribavirin
    • Taking ribavirin with Zepatier (elbasvir / grazoprevir)
  • Abnormally high liver test
    • Female
    • Asian
    • Age 65 or older
  • Drug interactions
See more detailed risks and warnings
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Slow heart rate
    • Amiodarone
    • Beta blockers
    • Heart disease
    • Liver disease
  • Drug interactions
    • Rifampin
    • St. John's wort
  • Ribavirin combination treatment
    • Taking ribavirin with Olysio (simeprevir)
  • Skin problems
    • Taking Olysio (simeprevir) in combination with rivabirin and peg-interferon alfa
See more detailed risks and warnings