Compare Zepatier vs. Viekira XR
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats hepatitis C.
Zepatier (elbasvir / grazoprevir) is a combination pill that treats hepatitis C genotypes 1 and 4, but it can't be used if you have moderate to severe liver disease.
A combination of 3 different medicines that treats hepatitis C infection.
Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is a once daily drug regimen consisting of 3 pills a day that are effective against genotype 1 hepatitis C virus, but may not be a good option if you have liver problems.
Upsides
- Zepatier (elbasvir / grazoprevir) can cure hepatitis C, which means the virus can't be detected in the blood 3 months after completing treatment.
- If you only need to take Zepatier (elbasvir / grazoprevir), it’s just 1 pill once a day for 12 or 16 weeks.
- Zepatier (elbasvir / grazoprevir) can be taken by people with kidney problems, even those on hemodialysis.
- Zepatier (elbasvir / grazoprevir) usually has mild side effects.
- Unlike Viekira Pak, Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is only three pills that is taken all at once.
- Similar to Viekira Pak, Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) has a 95% to 100% cure rate.
- Common side effects are manageable and include feeling nauseous, tired, itching, or rash.
- Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) can also be used to treat genotype 1 hepatitis C if you have a liver transplant.
Downsides
- Zepatier (elbasvir / grazoprevir) doesn't work for all genotypes of hepatitis C. It should only be used for genotype 1 or 4.
- Some people need to take Zepatier (elbasvir / grazoprevir) together with another medication called ribavirin. Ribavirin has its own set of side effects.
- You shouldn’t take Zepatier (elbasvir / grazoprevir) if you have moderate to severe liver disease.
- If you've ever had hepatitis B virus infection, the virus could become active again during or after treatment with Zepatier (elbasvir / grazoprevir). Before starting it, your doctor will do blood tests to check for hepatitis B virus.
- Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is a combination of 3 different medications which may be hard to take if you don't like swallowing a lot of pills.
- You may need to take an additional medication called ribavirin with Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir).
- If you are taking ethinyl estradiol-containing medications, you will need another form of birth control during and for 2 weeks after using Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir).
- Should not be used if you experienced severe rash after taking ritonavir (Norvir).
- Your doctor will need to take frequent blood tests during the first 4 weeks, and periodically after to monitor your liver function.
Used for
- Hepatitis C infection genotype 1 and 4
- Hepatitis C infection genotype 1
Dosage forms
- Pill
- Pill
Price
Lowest price
$3590.16
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Reviews
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Side effects
6possible side effects
- Fatigue34%
- Nausea22%
- Itching18%
- Skin reactions16%
- Trouble sleeping14%
- Weakness/Lack of energy14%
Risks and risk factors
- Hepatitis B reactivation
- History of hepatitis B infection
- Risks and warnings of ribavirin
- Taking ribavirin with Zepatier (elbasvir / grazoprevir)
- Abnormally high liver test
- Female
- Asian
- Age 65 or older
- Drug interactions
- Hepatitis B reactivation
- Hepatitis B infection
- Serious liver problems and complications
- Moderate to severe liver disease (Child Pugh B or C)
- Raised liver blood tests
- Taking estrogen containing medications
- Ribavirin warnings
- Drug interactions
- HIV resistance
- HIV infection