Compare Zepatier vs. Viekira XR

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats hepatitis C.

Zepatier (elbasvir / grazoprevir) is a combination pill that treats hepatitis C genotypes 1 and 4, but it can't be used if you have moderate to severe liver disease.

A combination of 3 different medicines that treats hepatitis C infection.

Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is a once daily drug regimen consisting of 3 pills a day that are effective against genotype 1 hepatitis C virus, but may not be a good option if you have liver problems.

Upsides
  • Zepatier (elbasvir / grazoprevir) can cure hepatitis C, which means the virus can't be detected in the blood 3 months after completing treatment.
  • If you only need to take Zepatier (elbasvir / grazoprevir), it’s just 1 pill once a day for 12 or 16 weeks.
  • Zepatier (elbasvir / grazoprevir) can be taken by people with kidney problems, even those on hemodialysis.
  • Zepatier (elbasvir / grazoprevir) usually has mild side effects.
  • Unlike Viekira Pak, Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is only three pills that is taken all at once.
  • Similar to Viekira Pak, Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) has a 95% to 100% cure rate.
  • Common side effects are manageable and include feeling nauseous, tired, itching, or rash.
  • Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) can also be used to treat genotype 1 hepatitis C if you have a liver transplant.
Downsides
  • Zepatier (elbasvir / grazoprevir) doesn't work for all genotypes of hepatitis C. It should only be used for genotype 1 or 4.
  • Some people need to take Zepatier (elbasvir / grazoprevir) together with another medication called ribavirin. Ribavirin has its own set of side effects.
  • You shouldn’t take Zepatier (elbasvir / grazoprevir) if you have moderate to severe liver disease.
  • If you've ever had hepatitis B virus infection, the virus could become active again during or after treatment with Zepatier (elbasvir / grazoprevir). Before starting it, your doctor will do blood tests to check for hepatitis B virus.
  • Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir) is a combination of 3 different medications which may be hard to take if you don't like swallowing a lot of pills.
  • You may need to take an additional medication called ribavirin with Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir).
  • If you are taking ethinyl estradiol-containing medications, you will need another form of birth control during and for 2 weeks after using Viekira XR (ombitasvir, paritaprevir, ritonavir, and dasabuvir).
  • Should not be used if you experienced severe rash after taking ritonavir (Norvir).
  • Your doctor will need to take frequent blood tests during the first 4 weeks, and periodically after to monitor your liver function.
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Used for
  • Hepatitis C infection genotype 1 and 4
  • Hepatitis C infection genotype 1
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$3598.90
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Reviews
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Side effects
3possible side effects
  • Nausea
    11%
  • Headache
    11%
  • Tiredness
    5%
See more detailed side effects
6possible side effects
  • Fatigue
    34%
  • Nausea
    22%
  • Itching
    18%
  • Skin reactions
    16%
  • Trouble sleeping
    14%
  • Weakness/Lack of energy
    14%
See more detailed side effects
Risks and risk factors
  • Hepatitis B reactivation
    • History of hepatitis B infection
  • Risks and warnings of ribavirin
    • Taking ribavirin with Zepatier (elbasvir / grazoprevir)
  • Abnormally high liver test
    • Female
    • Asian
    • Age 65 or older
  • Drug interactions
See more detailed risks and warnings
  • Hepatitis B reactivation
    • Hepatitis B infection
  • Serious liver problems and complications
    • Moderate to severe liver disease (Child Pugh B or C)
  • Raised liver blood tests
    • Taking estrogen containing medications
  • Ribavirin warnings
  • Drug interactions
  • HIV resistance
    • HIV infection
See more detailed risks and warnings