Compare Zestoretic vs. Benicar HCT

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood pressure.

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

3.4/ 5 average rating with 294 reviewsforZestoretic
Lowers blood pressure.

Benicar HCT is a good 2-in-1 blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.

3.5/ 5 average rating with 67 reviewsforBenicar HCT
Upsides
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Benicar HCT work together to lower blood pressure and remove extra water from your body.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
  • Not available in less expensive generic form.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
294 reviews so far
51%
saidit'sworth it
40%
saiditworked well
17%
saidit'sa big hassle

Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?

Leave a review
67 reviews so far
57%
saidit'sworth it
45%
saiditworked well
30%
saidit'sa big hassle

Have you used Benicar Hct (Olmesartan / Hydrochlorothiazide)?

Leave a review
Side effects
11possible side effects
  • Dizziness
    8%
  • Headache
    5%
  • Cough
    4%
  • Fatigue
    4%
  • Orthostatic Effects
    3%
  • Diarrhea
    3%
  • Nausea
    2%
  • Upper Respiratory Infection
    2%
  • Muscle Cramps
    2%
  • Asthenia
    2%
  • Paresthesia
    2%
See more detailed side effects
4possible side effects
  • Dizziness
    9%
  • Upper respiratory tract infection
    7%
  • Hyperuricemia
    4%
  • Nausea
    3%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Unusual tongue swelling
    • African descent
  • Severe allergic reactions while on dialysis
    • People requiring high flux dialysis
  • Acute kidney failure
    • History of kidney disease
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
  • Cough
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Unusual tongue swelling
    • African descent
  • Diarrhea
  • Lupus
    • History of lupus
  • Acute nearsightedness or glaucoma
    • Allergies to penicillin or sulfonamides
  • Liver damage/jaundice
    • Prior history of impaired liver function
  • Gout
    • History of gout
    • Current kidney problems
  • Liver damage
    • Prior history of impaired liver function
See more detailed risks and warnings