Compare Zetia vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zetia (ezetimibe)

Prescription only

Trilipix (Fenofibric Acid)

Prescription only
Lowers cholesterol.

Zetia (ezetimibe) can improve your cholesterol and can be used as an alternative to statins.

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3.3/ 5 average rating with 128 reviewsforZetia
Lowers cholesterol.

Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.

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2.9/ 5 average rating with 68 reviewsforTrilipix
Upsides
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Can be used with other medicines to improve cholesterol.
  • Available in a combination pill with simvastatin.
  • Available as a generic.
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
Downsides
  • Doesn't lower triglycerides (fats).
  • Hasn't been shown to lower the risk of heart attacks or heart disease.
  • By itself, it isn't as effective as statins for improving cholesterol.
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
Lowest price
$21.49
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Lowest price
$22.04
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Reviews
128 reviews so far
42%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

Have you used Zetia (ezetimibe)?

Leave a review
68 reviews so far
50%
saidit'sworth it
22%
saiditworked well
25%
saidit'sa big hassle

Have you used Trilipix (Fenofibric Acid)?

Leave a review
Side effects
12possible side effects
  • Diarrhea
    4%
  • Common cold
    4%
  • Sore throat
    4%
  • Sinus infection
    3%
  • Joint pain
    3%
  • Pain in arms and legs
    3%
  • Muscle pain
    3%
  • Abnormal liver tests
    3%
  • Fatigue
    2%
  • Flu
    2%
  • Back pain
    2%
  • Gallbladder removal
    2%
See more detailed side effects
The Trilipix (Fenofibric Acid) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Harm to fetus
  • Muscle pain
    • Taking Zetia (ezetimibe) with statins
  • Abnormal liver blood tests
    • Past history of liver disease
    • Taking Zetia (ezetimibe) with statins
See more detailed risks and warnings
  • Muscle pain
    • Taking Trilipix (Fenofibric Acid) with statins
  • Liver damage
    • Past history of liver disease
  • Gallstones
  • Increased bleeding risk
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
  • Pancreatitis
  • Changes in blood tests
  • Skin reactions
  • Blood clots
  • Increased risk for colds and flu
See more detailed risks and warnings
Learn more about Zetia (ezetimibe)
Learn more about Trilipix (Fenofibric Acid)