Compare Zioptan vs. brimonidine

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Zioptan (tafluprost)

Prescription only

Alphagan P (brimonidine)

Prescription only
Lowers eye pressure and controls glaucoma.

Zioptan (tafluprost) is often a first choice treatment for lowering eye pressure to prevent and treat glaucoma, but is preservative-free so it has special storage instructions.

Lowers high eye pressure.

Alphagan P (brimonidine) is an effective medication for treating high pressure in the eyes, but it can cause some bothersome effects such as dry mouth, eye burning, and stinging upon administration.

  • Easy to use, with single-use containers and one drop daily in the evening.
  • Can use with other eye drops, if needed for better results.
  • Zioptan (tafluprost) is the only medicine in its class without preservatives, which may be less irritating to the eye.
  • Alphagan P (brimonidine) is a good medication for reducing high eye pressure and helping prevent development of glaucoma.
  • It is available as a cheaper, generic form.
  • Zioptan (tafluprost) can permanently change your eyes and eyelids to brown, even after you stop using it.
  • Zioptan (tafluprost) may darken and increase the length, thickness and number of eyelashes, irritating the eyes.
  • No generic available, so can be expensive.
  • Is preservative-free so it should only be used 30 days after opening.
  • Even though it's administered in the eye, Alphagan P (brimonidine) can make you feel fatigued and drowsy.
  • You must wait 5 minutes before using another eye drop in the same eye.
  • You have to remove contact lenses and leave them out for 15 minutes after using the eyedrops.
  • Alphagan P (brimonidine) can't be used in children under 2 years of age.
Used for
  • Elevated intraocular pressure
Dosage forms
  • Eye drops
  • Eye drops
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Side effects
4possible side effects
  • Heache
  • Common cold
  • Cough
  • Blurry vision
See more detailed side effects
The Alphagan P (brimonidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Darkening of the eyes
    • Long term use
  • Darkening of lashes
    • Long term use
  • Darkening of contact lenses
    • (Re)inserting contact lenses too soon after applying Zioptan (tafluprost)
  • Eye injury/infection
    • Sharing eye drops with others
See more detailed risks and warnings
  • Contact lens use
  • Contamination of eye products after use
    • Corneal disease
    • Disruption of the ocular epithelial surface
  • Severe heart disease
  • CNS depression (sleepiness and fatigue)
See more detailed risks and warnings