Compare Zioptan vs. Combigan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers eye pressure and controls glaucoma.

Zioptan (tafluprost) is often a first choice treatment for lowering eye pressure to prevent and treat glaucoma, but is preservative-free so it has special storage instructions.

An eyedrop used to treat increased pressure inside the eye

An effective control of high pressure within the eye when used alone or with other eye medications. Lowering eye pressure back to normal can prevent the onset of glaucoma.

  • Easy to use, with single-use containers and one drop daily in the evening.
  • Can use with other eye drops, if needed for better results.
  • Zioptan (tafluprost) is the only medicine in its class without preservatives, which may be less irritating to the eye.
  • The two medicines do not have to be taken separately
  • Zioptan (tafluprost) can permanently change your eyes and eyelids to brown, even after you stop using it.
  • Zioptan (tafluprost) may darken and increase the length, thickness and number of eyelashes, irritating the eyes.
  • No generic available, so can be expensive.
  • Is preservative-free so it should only be used 30 days after opening.
  • The medicine is absorbed into your body and therefore may react to other conditions you have, such as heart or lung conditions
Used for
  • Glaucoma
  • In patients requiring adjunctive or replacement therapy Ocular hypertension
  • In patients requiring adjunctive or replacement therapy
Dosage forms
  • Eye drops
  • Eye drops
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Side effects
4possible side effects
  • Heache
  • Common cold
  • Cough
  • Blurry vision
See more detailed side effects
The Combigan (Brimonidine / Timolol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Darkening of the eyes
    • Long term use
  • Darkening of lashes
    • Long term use
  • Darkening of contact lenses
    • (Re)inserting contact lenses too soon after applying Zioptan (tafluprost)
  • Eye injury/infection
    • Sharing eye drops with others
See more detailed risks and warnings
  • Heart problems (Cardiovascular Risk)
    • High blood Pressure
    • irregular heart beats
  • Lung conditions
    • People with Asthma, COPD, or other breathing conditions
  • Redness in eye
    • Long term use
  • Visual Changes
  • Young children
See more detailed risks and warnings