Compare Zofran vs. Anzemet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zofran (ondansetron)

Prescription only

Anzemet (dolasetron)

Prescription only
Helps prevent nausea and vomiting.

Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.

3.6/ 5 average rating with 366 reviewsforZofran
Helps prevent nausea and vomiting

Anzemet (dolasetron) prevents nausea and vomiting and does not have many side effects.

Upsides
  • Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
  • Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
  • Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
  • Reduced nausea and vomiting in people receiving chemotherapy.
  • Well-tolerated with mild headache as the most common side effect.
  • Requires only 1 dose prior to chemotherapy and once daily dosing after chemotherapy if needed for delayed nausea/vomiting.
Downsides
  • Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
  • If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
  • Anzemet (dolasetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Anzemet (dolasetron) can cause problems with heart rhythm.
  • Can be expensive since a generic version is not available.
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Used for
  • Nausea and vomiting due to cancer medicines
  • Prevention of nausea and vomiting due to radiation therapy and after surgery
  • Severe nausea and vomiting in pregnancy
Dosage forms
  • Pill
  • Disintegrating tablet
  • Liquid
  • Sublingual film
  • Pill
Price
Lowest price
$2853.69
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle

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Side effects
8possible side effects
  • Headache
    9%
  • Oxygen deficiency
    9%
  • Fever
    8%
  • Dizziness
    7%
  • Gynecologic problems
    7%
  • Anxiety
    6%
  • Problems urinating
    5%
  • Itching
    5%
See more detailed side effects
9possible side effects
  • Headache
    23%
  • Fatigue
    6%
  • Diarrhea
    5%
  • Decreased heart rate
    4%
  • Dizziness
    3%
  • Pain
    3%
  • Increased heart rate
    3%
  • Indigestion
    2%
  • Chills/shivering
    2%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).
  • Heart rhythm problems
    • History of long QT syndrome
    • Very high doses of Zofran (ondansetron)
    • Taking other medicines causing heart rhythm problems
    • Low magneium or potassium
    • Heart failure
  • Masking of intestinal blockage and stomach bloating
    • Abdominal surgery
    • Chemotherapy
See more detailed risks and warnings
  • Abnormal heart rhythm
    • History of heart rhythms such as long QT syndrome or atrial fibrillation
    • Heart failure
    • Taking other medications that can affect heart rhythms
    • Low potassium or magnesium levels
    • Advanced age
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
See more detailed risks and warnings