Compare Zofran vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zofran (Ondansetron)

Prescription only

Compro (Prochlorperazine)

Prescription only
Helps you feel less queasy.

Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.

3.6/ 5 average rating with 366 reviewsforZofran
Helps you feel less queasy.

Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.

3.0/ 5 average rating with 20 reviewsforCompro
Upsides
  • Available in generic.
  • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
  • Starts working fast (in 30 minutes.
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
Downsides
  • Can cause headaches.
  • Can interact with antidepressants.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Pill
  • Suppository
Price
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle

Have you used Zofran (Ondansetron)?

Leave a review
20 reviews so far
45%
saidit'sworth it
35%
saiditworked well
35%
saidit'sa big hassle

Have you used Compro (Prochlorperazine)?

Leave a review
Side effects
5possible side effects
  • Headache
    17%
  • Diarrhea
    16%
  • Constipation
    11%
  • Fever
    8%
  • Increased AST and ALT
    5%
See more detailed side effects
The Compro (Prochlorperazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
  • Heart rhythm problems
    • Long QT syndrome
See more detailed risks and warnings
  • Increased risk of death
    • Over age 65
    • Dementia
    • Taking antipsychotics
  • Seizures
    • History of seizures
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
  • Heatstroke
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings