Compare Zofran vs. Compro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zofran (ondansetron)

Prescription only

Compro (Prochlorperazine)

Prescription only
Helps prevent nausea and vomiting.

Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.

3.6/ 5 average rating with 366 reviewsforZofran
Helps you feel less queasy.

Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.

3.0/ 5 average rating with 20 reviewsforCompro
Upsides
  • Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
  • Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
  • Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
  • Available in generic, so it's cheap.
  • Can be taken by mouth, as a shot, or rectally.
  • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
Downsides
  • Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
  • If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
  • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
  • Can't be used by people over 65 because they can be more affected by the side effects.
  • It can make you more likely to get heatstroke.
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Used for
  • Nausea and vomiting due to cancer medicines
  • Prevention of nausea and vomiting due to radiation therapy and after surgery
  • Severe nausea and vomiting in pregnancy
Dosage forms
  • Pill
  • Disintegrating tablet
  • Liquid
  • Sublingual film
  • Pill
  • Suppository
Price
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle

Have you used Zofran (ondansetron)?

Leave a review
20 reviews so far
45%
saidit'sworth it
35%
saiditworked well
35%
saidit'sa big hassle

Have you used Compro (Prochlorperazine)?

Leave a review
Side effects
8possible side effects
  • Headache
    9%
  • Oxygen deficiency
    9%
  • Fever
    8%
  • Dizziness
    7%
  • Gynecologic problems
    7%
  • Anxiety
    6%
  • Problems urinating
    5%
  • Itching
    5%
See more detailed side effects
The Compro (Prochlorperazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).
  • Heart rhythm problems
    • History of long QT syndrome
    • Very high doses of Zofran (ondansetron)
    • Taking other medicines causing heart rhythm problems
    • Low magneium or potassium
    • Heart failure
  • Masking of intestinal blockage and stomach bloating
    • Abdominal surgery
    • Chemotherapy
See more detailed risks and warnings
  • Increased risk of death
    • Over age 65
    • Dementia
    • Taking antipsychotics
  • Seizures
    • History of seizures
  • Involuntary muscle movements
    • Age over 65
  • Neuroleptic malignant syndrome
  • Heatstroke
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings