Compare Zofran vs. granisetron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zofran (ondansetron)

Prescription only

granisetron

Prescription only
Helps prevent nausea and vomiting.

Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.

3.6/ 5 average rating with 366 reviewsforZofran
Helps prevent nausea and vomiting due to chemotherapy or radiation treatment

granisetron is a safe and effective medication used for preventing nausea and vomiting due to chemotherapy and radiation, but it can be very expensive.

Upsides
  • Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
  • Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
  • Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
  • granisetron is effective even for those who are using chemotherapy that is associated with a high risk for causing nausea and vomiting.
  • Safe and effective option for older people, unlike some other alternatives.
  • You only need to take granisetron on the days you actually receive chemotherapy and radiation.
  • A patch form of the medication is available for those who don't want to or who are unable to take pills.
  • Safe to use for people with kidney problems.
Downsides
  • Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
  • If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
  • granisetron only prevents symptoms of nausea and vomiting so you must take the medication before you get chemotherapy or radiation treatment.
  • Can affect the natural rhythm of your heart, especially if you take other medications that can also potentially cause the same problem.
  • Might not be a good option for those who are on certain antidepressants.
  • granisetron is very expensive compared to similar alternatives.
  • Very likely to cause side effects like headache and constipation.
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Used for
  • Nausea and vomiting due to cancer medicines
  • Prevention of nausea and vomiting due to radiation therapy and after surgery
  • Severe nausea and vomiting in pregnancy
  • Prevention of chemotherapy-associated nausea and vomiting
  • Prevention of radiation-associated nausea and vomiting
  • Prevention of post-surgery nausea and vomiting
Dosage forms
  • Pill
  • Disintegrating tablet
  • Liquid
  • Sublingual film
  • Pill
Price
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle

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Side effects
8possible side effects
  • Headache
    9%
  • Oxygen deficiency
    9%
  • Fever
    8%
  • Dizziness
    7%
  • Gynecologic problems
    7%
  • Anxiety
    6%
  • Problems urinating
    5%
  • Itching
    5%
See more detailed side effects
6possible side effects
  • Headache
    20%
  • Weakness
    18%
  • Constipation
    14%
  • Diarrhea
    9%
  • Indigestion
    6%
  • Stomach pain
    4%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).
  • Heart rhythm problems
    • History of long QT syndrome
    • Very high doses of Zofran (ondansetron)
    • Taking other medicines causing heart rhythm problems
    • Low magneium or potassium
    • Heart failure
  • Masking of intestinal blockage and stomach bloating
    • Abdominal surgery
    • Chemotherapy
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking other medications that also affect serotonin levels in the brain
  • Effects on heart
    • History of arrhythmias
    • Taking other medications that can also cause irregular heartbeat
    • Electrolyte imbalance
  • Constipation
    • History of constipation problems
    • Those who had recent abdominal surgery
See more detailed risks and warnings