Compare Zofran vs. Reglan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zofran (ondansetron)

Prescription only

Reglan (metoclopramide)

Prescription only
Helps prevent nausea and vomiting.

Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.

3.6/ 5 average rating with 366 reviewsforZofran
Relieves nausea and vomiting.

Reglan (metoclopramide) can stimulate your gut and relieve nausea, but it can only be used for a short period of time due to avoid serious side-effects.

Upsides
  • Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
  • Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
  • Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
  • Especially useful for relieving nausea caused by cancer chemotherapy.
  • Available in an affordable, generic version
  • If tablets are hard for you to swallow, Reglan (metoclopramide) is also available in as an orally disintegrating tablet or liquid form.
Downsides
  • Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
  • If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
  • Use for more than 12 weeks can cause involuntary movements of the eyes, tongue, face, arm, or legs.
  • May take a while to relieve nausea and vomiting caused by delayed gastric emptying.
  • Not a good option if you have Parkinson's disease, history of seizures, or blockage in your gut.
  • You may need a lower dose if you have kidney problems.
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Used for
  • Nausea and vomiting due to cancer medicines
  • Prevention of nausea and vomiting due to radiation therapy and after surgery
  • Severe nausea and vomiting in pregnancy
  • Diabetic gastroparesis
  • Gastroesophegeal reflux
  • Prevention of nausea and vomiting associated with chemotherapy
  • Prevention of postoperative nausea and vomiting
  • Radiological exam
  • Small bowel intubation
  • Gastric bezoars
  • Hiccups
  • Acute migraine
  • Treatment of nausea and vomiting in advanced cancer
  • Prevention of radiation therapy-induced nausea and vomiting
Dosage forms
  • Pill
  • Disintegrating tablet
  • Liquid
  • Sublingual film
  • Pill
  • Dissolving tablet
  • Liquid
  • Injectable
Price
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle

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Side effects
8possible side effects
  • Headache
    9%
  • Oxygen deficiency
    9%
  • Fever
    8%
  • Dizziness
    7%
  • Gynecologic problems
    7%
  • Anxiety
    6%
  • Problems urinating
    5%
  • Itching
    5%
See more detailed side effects
4possible side effects
  • Restlessness
    10%
  • Drowsiness
    10%
  • Fatigue
    10%
  • Lack of energy
    10%
See more detailed side effects
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).
  • Heart rhythm problems
    • History of long QT syndrome
    • Very high doses of Zofran (ondansetron)
    • Taking other medicines causing heart rhythm problems
    • Low magneium or potassium
    • Heart failure
  • Masking of intestinal blockage and stomach bloating
    • Abdominal surgery
    • Chemotherapy
See more detailed risks and warnings
  • Late, irreversible, involuntary movements (tardive dyskinesia)
    • Elderly
    • Women
    • Diabetics
  • Depression
    • Depression
  • Neuroleptic malignant syndrome
  • Early, reversible involuntary movements (extrapyramidal side-effects)
    • Younger than 30 years old
    • High doses of Reglan (metoclopramide)
    • Children and teens
See more detailed risks and warnings