Compare Zofran vs. scopolamine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zofran (Ondansetron)

Prescription only
Helps you feel less queasy.

Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.

3.6/ 5 average rating with 366 reviewsforZofran
Prevents nausea and vomiting.

Transderm-Scop (scopolamine) is a low-hassle patch that works well to prevent nausea and vomiting, but it takes several hours to work.

3.9/ 5 average rating with 26 reviewsforscopolamine
Upsides
  • Available in generic.
  • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
  • Starts working fast (in 30 minutes.
  • Transderm-Scop (scopolamine) is well tolerated.
  • Prevents nausea for 3 days.
  • Because Transderm-Scop (scopolamine) is a skin patch, it's a good alternative to stopping nausea and vomiting if you're not able to swallow pills.
Downsides
  • Can cause headaches.
  • Can interact with antidepressants.
  • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
  • Can only be used for prevention of nausea and vomiting. It can't stop nausea or vomiting that's already happening.
  • The side effects can be worse if you are 65 and older.
  • You might feel sleepy, drowsy, or have blurry vision while taking Transderm-Scop (scopolamine). Taking alcohol or other medicines that make you drowsy can make this effect worse.
  • You're more likely to have heat stroke or feel dehydrated.
  • It takes a few hours for Transderm-Scop (scopolamine) to kick in, so you have to remember to take it beforehand.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Patch
Price
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle

Have you used Zofran (Ondansetron)?

Leave a review
26 reviews so far
73%
saidit'sworth it
58%
saiditworked well
19%
saidit'sa big hassle

Have you used Transderm-Scop (scopolamine)?

Leave a review
Side effects
5possible side effects
  • Headache
    17%
  • Diarrhea
    16%
  • Constipation
    11%
  • Fever
    8%
  • Increased AST and ALT
    5%
See more detailed side effects
The Transderm-Scop (scopolamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
  • Heart rhythm problems
    • Long QT syndrome
See more detailed risks and warnings
  • Increased pressure in the eyes
    • Open angle glaucoma
  • Worsening stomach, bowel, or bladder blockages
    • Blockages in the stomach, bowels or bladder
  • Skin burns
    • MRI examination
  • Heat stroke
  • Worsening seizures or psychosis
    • History of seizures
    • History of psychosis
  • Sleepiness and dizziness
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings