Compare Zofran vs. Sustol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Helps prevent nausea and vomiting.

Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.

3.6/ 5 average rating with 366 reviewsforZofran
Helps prevent nausea and vomiting due to cancer chemotherapies.

Sustol (granisetron) is a long-acting injection that helps to prevent nausea and vomiting due to cancer chemotherapies, but causes bleeding and bruising at the injection site.

  • Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
  • Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
  • Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
  • Each dose of Sustol (granisetron) provides relief from nausea and vomiting for at least 7 days.
  • Dosing is less frequent than alternatives.
  • Injection may be preferrable if you have difficulty swallowing a pill.
  • Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
  • If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
  • Sustol (granisetron) must be given at the doctor's office or infusion center 30 minutes before chemotherapy.
  • The dose of Sustol (granisetron) needs to be adjusted if you have poor kidney function.
  • Available as an expensive, branded product only.
Used for
  • Nausea and vomiting due to cancer medicines
  • Prevention of nausea and vomiting due to radiation therapy and after surgery
  • Severe nausea and vomiting in pregnancy
  • Prevention of nausea and vomiting due to cancer chemotherapy
Dosage forms
  • Pill
  • Disintegrating tablet
  • Liquid
  • Sublingual film
  • Extended-release injection
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
366 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Zofran (ondansetron)?

Leave a review
Not enough review data.Leave a review
Side effects
8possible side effects
  • Headache
  • Oxygen deficiency
  • Fever
  • Dizziness
  • Gynecologic problems
  • Anxiety
  • Problems urinating
  • Itching
See more detailed side effects
The Sustol (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Serotonin syndrome
    • Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).
  • Heart rhythm problems
    • History of long QT syndrome
    • Very high doses of Zofran (ondansetron)
    • Taking other medicines causing heart rhythm problems
    • Low magneium or potassium
    • Heart failure
  • Masking of intestinal blockage and stomach bloating
    • Abdominal surgery
    • Chemotherapy
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels such as anti-depressants
  • Troublesome stomach side-effects (ileus)
    • Taking other medications that cause constipation such as Norco and Percocet.
  • Injection site reactions
    • Bruising/bleeding more likely if also taking medications that affect blood coagulation
  • Allergic reactions
See more detailed risks and warnings