Compare Zofran vs. Zyprexa
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Helps prevent nausea and vomiting.
Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.
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3.6/ 5 average rating with 366 reviewsforZofran
Helps control your thoughts and mood.
Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.
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3.7/ 5 average rating with 68 reviewsforZyprexa
Upsides
- Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
- Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
- Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
- Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
- Less likely to cause heart problems than other antipsychotics.
- Less likely to cause movement problems compared to older antipsychotics.
Downsides
- Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
- High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
- If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
- More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
- Might make you more sleepy than some antipsychotics.
- Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
- You may need routine blood tests to check how the medicine is affecting your body..
Used for
- Nausea and vomiting due to cancer medicines
- Prevention of nausea and vomiting due to radiation therapy and after surgery
- Severe nausea and vomiting in pregnancy
Dosage forms
- Pill
- Disintegrating tablet
- Liquid
- Sublingual film
- Pill
- Dissolving tablet
- Injection
Price
Lowest price
$341.34
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$223.48
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Reviews
366 reviews so far
66%
saidit'sworth it
51%
saiditworked well
15%
saidit'sa big hassle
Have you used Zofran (ondansetron)?
Leave a review68 reviews so far
41%
saidit'sworth it
51%
saiditworked well
51%
saidit'sa big hassle
Have you used Zyprexa (olanzapine)?
Leave a reviewSide effects
8possible side effects
- Headache9%
- Oxygen deficiency9%
- Fever8%
- Dizziness7%
- Gynecologic problems7%
- Anxiety6%
- Problems urinating5%
- Itching5%
9possible side effects
- Drowsiness48%
- Weight gain28%
- Increased appetite28%
- Headache17%
- Fatigue14%
- Dizziness7%
- Dry Mouth7%
- Abdominal pain6%
- Pain in extremity5%
Risks and risk factors
- Serotonin syndrome
- Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).
- Heart rhythm problems
- History of long QT syndrome
- Very high doses of Zofran (ondansetron)
- Taking other medicines causing heart rhythm problems
- Low magneium or potassium
- Heart failure
- Masking of intestinal blockage and stomach bloating
- Abdominal surgery
- Chemotherapy
- Increased risk of death
- Elderly patients with dementia
- Blood disorders
- Neuroleptic malignant syndrome
- Heart problems
- History of heart problems
- Drug interactions
- Shaking and restlessness
- Higher blood sugar, high cholesterol, and weight gain
- People with diabetes
- People with high cholesterol