Compare Zoloft vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zoloft (sertraline)

Prescription only

Klonopin (clonazepam)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

3.5/ 5 average rating with 1472 reviewsforZoloft
Controls seizures and helps panic attacks.

Klonopin (clonazepam) can be used for immediate relief of panic attacks and seizures, but is not intended for long-term management.

3.8/ 5 average rating with 767 reviewsforKlonopin
Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • More people who took Klonopin (clonazepam) were free of panic attacks, compared to people who did not take Klonopin (clonazepam).
  • Klonopin (clonazepam) works quickly, within the hour.
  • Can be used together with antidepressants to manage panic disorder.
  • Klonopin (clonazepam) lasts longer and has less severe withdrawal symptoms compared to other similar medicines.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Klonopin (clonazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Klonopin (clonazepam) can be habit-forming, so is not typically used for long-term treatment.
  • May require higher doses of Klonopin (clonazepam) over time to establish the same seizure control.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Price
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Reviews
1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle

Have you used Zoloft (sertraline)?

Leave a review
767 reviews so far
70%
saidit'sworth it
52%
saiditworked well
14%
saidit'sa big hassle

Have you used Klonopin (clonazepam)?

Leave a review
Side effects
15possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
  • Ejaculation failure
    7%
  • Upset stomach
    6%
  • Agitation
    6%
  • Loss of appetite
    3%
  • Stomach pain
    2%
See more detailed side effects
4possible side effects
  • Drowsiness
    37%
  • Depression
    7%
  • Abnormal coordination
    6%
  • Loss of full control of bodily movements
    5%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Mania
    • Personal history of bipolar disorder
    • Family history for bipolar disorder
  • Withdrawal
    • Stopping Zoloft (sertraline) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Low sodium levels in the blood
    • Older people
    • Taking diuretic medicines
See more detailed risks and warnings
  • Sedation, respiratory depression, coma and death
    • Taking with opioids
    • Drinking alcohol
  • Dependence and withdrawal
    • Taking high dosage
    • Taking long-term
    • History of drug abuse
  • Driving impairment
    • Drinking alcohol
    • Taking other medicines that make you less alert
  • Suicidal behavior and ideation
See more detailed risks and warnings