Compare Zoloft vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zoloft (sertraline)

Prescription only

Valium (diazepam)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

3.5/ 5 average rating with 1472 reviewsforZoloft
Helps you relax.

Valium (diazepam) is effective for occasional or short-term use for anxiety and muscle spasm. Compared to similar drugs, Valium (diazepam) acts very quickly but can have interactions with other medicines.

3.8/ 5 average rating with 976 reviewsforValium
Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • Valium (diazepam) effectively relieves anxiety and muscle spasms.
  • Valium (diazepam) has less severe withdrawal symptoms compared to other similar drugs.
  • Works very quickly.
  • Available in generic.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Use of Valium (diazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Valium (diazepam) can be habit-forming, so it's not typically used for long-term treatment.
  • Most people find that their body will get used to Valium (diazepam) levels and they may need higher doses over time to achieve the same effect.
  • People with severe liver problems should not take Valium (diazepam). Several drugs can also interfere with how Valium (diazepam) works.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle

Have you used Zoloft (sertraline)?

Leave a review
976 reviews so far
70%
saidit'sworth it
53%
saiditworked well
15%
saidit'sa big hassle

Have you used Valium (diazepam)?

Leave a review
Side effects
15possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
  • Ejaculation failure
    7%
  • Upset stomach
    6%
  • Agitation
    6%
  • Loss of appetite
    3%
  • Stomach pain
    2%
See more detailed side effects
The Valium (diazepam) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Mania
    • Personal history of bipolar disorder
    • Family history for bipolar disorder
  • Withdrawal
    • Stopping Zoloft (sertraline) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Low sodium levels in the blood
    • Older people
    • Taking diuretic medicines
See more detailed risks and warnings
  • Decreased breathing from use with opioids
    • Taking Valium (diazepam) with opioids, drugs or alcohol
    • Using Valium (diazepam) for a longer duration and at high doses
  • Dependence and withdrawal
    • History of substance abuse
    • Taking with alcohol or drugs
    • Taking long-term
    • Taking a higher dose
    • Stopping Valium (diazepam) suddenly
  • Driving impairment
    • Alcohol use with Valium (diazepam)
    • Taking other medicines that make you less alert
  • Drug interactions
    • Current liver problems
    • Taking Tagamet, ketoconazole, Prozac, Prilosec
See more detailed risks and warnings