Compare Zoloft vs. Wellbutrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zoloft (sertraline)

Prescription only

Wellbutrin (Bupropion)

Prescription only
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

3.5/ 5 average rating with 1472 reviewsforZoloft
Improves mood.

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

3.4/ 5 average rating with 1164 reviewsforWellbutrin
Upsides
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
Price
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Reviews
1472 reviews so far
59%
saidit'sworth it
41%
saiditworked well
15%
saidit'sa big hassle

Have you used Zoloft (sertraline)?

Leave a review
1164 reviews so far
60%
saidit'sworth it
40%
saiditworked well
13%
saidit'sa big hassle

Have you used Wellbutrin (Bupropion)?

Leave a review
Side effects
15possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
  • Ejaculation failure
    7%
  • Upset stomach
    6%
  • Agitation
    6%
  • Loss of appetite
    3%
  • Stomach pain
    2%
See more detailed side effects
29possible side effects
  • Agitation
    32%
  • Dry mouth
    28%
  • Constipation
    26%
  • Headache/migraine
    26%
  • Nausea/vomiting
    23%
  • Dizziness
    22%
  • Excessive sweating
    22%
  • Tremor
    21%
  • Sleepiness
    20%
  • Insomnia
    19%
  • Blurred vision
    15%
  • Tachycardia
    11%
  • Confusion
    8%
  • Rash
    8%
  • Hostility
    6%
  • Auditory disturbance
    5%
  • Menstrual complaints
    5%
  • Cardiac arrhythmias
    5%
  • Impaired sleep quality
    4%
  • Sensory disturbance
    4%
  • Appetite increase
    4%
  • Palpitations
    4%
  • Hypertension
    4%
  • Impotence
    3%
  • Anxiety
    3%
  • Decreased libido
    3%
  • Gustatory disturbance
    3%
  • Dyspepsia
    3%
  • Hypotension
    3%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels
  • Mania
    • Personal history of bipolar disorder
    • Family history for bipolar disorder
  • Withdrawal
    • Stopping Zoloft (sertraline) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Low sodium levels in the blood
    • Older people
    • Taking diuretic medicines
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Psychiatric effects for smoking cessation
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine
  • Seizures
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Weight loss
See more detailed risks and warnings