Compare Zonegran vs. Aptiom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zonegran (zonisamide)

Prescription only

Aptiom (eslicarbazepine)

Prescription only
Controls partial seizures.

Zonegran (zonisamide) is used with other medicines to help control partial seizures. It can't be used by itself.

Prevents seizures

Aptiom (eslicarbazepine) treats epilepsy, but is more expensive than other medicines that work like it.

Upsides
  • Available in generic.
  • Can be given once a day, so it's easier to remember.
  • You can take Zonegran (zonisamide) with or without food.
  • Can be combined with other anti-seizure medicines if it doesn't work well enough by itself.
  • Some people may tolerate Aptiom (eslicarbazepine) better than other medicines that work just like it.
Downsides
  • Zonegran (zonisamide) has to be used with other medicines to help control your seizures. It's not used by itself.
  • Zonegran (zonisamide) is only approved in people age 16 or older.
  • Zonegran (zonisamide) can cause kidney stones; so you have to make sure you drink plenty of liquids.
  • Zonegran (zonisamide) can weaken your bones. Talk to your doctor about how to keep your bones strong.
  • Other medicines used to control seizures can interact with Zonegran (zonisamide), so your doctor might have to change the dosing of your medications.
  • More expensive than other medicines that work like it.
  • Researchers do not know if this medicine works and is safe for children and elderly people.
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Used for
Dosage forms
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Price
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Reviews
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Side effects
34possible side effects
  • Sleepiness
    17%
  • Loss of appetite
    13%
  • Dizziness
    13%
  • Headache
    10%
  • Nausea
    9%
  • Agitation or Irritability
    9%
  • Fatigue
    8%
  • Tiredness
    7%
  • Stomach pain
    6%
  • Difficulty controlling movements
    6%
  • Confusion
    6%
  • Difficulty with concentration
    6%
  • Difficulty with memory
    6%
  • Depression
    6%
  • Trouble sleeping
    6%
  • Double vision
    6%
  • Diarrhea
    5%
  • Speech difficulties
    5%
  • Flu
    4%
  • Difficulty controlling eye movements
    4%
  • Prickling and tingling sensation
    4%
  • Mental slowing
    4%
  • Upset stomach
    3%
  • Weight loss
    3%
  • Anxiety
    3%
  • Skin rash
    3%
  • Constipation
    2%
  • Dry mouth
    2%
  • Bruising
    2%
  • Nervousness
    2%
  • Schizophrenia-like behavior
    2%
  • Difficulties in verbal expression
    2%
  • Stuffy nose
    2%
  • Changes in taste
    2%
See more detailed side effects
25possible side effects
  • Dizziness
    20%
  • Headache
    13%
  • Drowsiness
    11%
  • Nausea
    10%
  • Double vision
    9%
  • Blurry vision
    6%
  • Vomiting
    6%
  • Diarrhea
    4%
  • Fatigue
    4%
  • Inability to control your movements
    4%
  • Falls
    3%
  • Loss of balance
    3%
  • Dizziness or spinning sensation
    2%
  • Other vision problems
    2%
  • Constipation
    2%
  • Abdominal pain
    2%
  • Inflammation of stomach
    2%
  • Lack of energy
    2%
  • Problems with walking
    2%
  • Swelling of the hands and feet
    2%
  • Urinary tract infections
    2%
  • Low sodium levels
    2%
  • Tremor
    2%
  • Insomnia
    2%
  • Cough
    2%
See more detailed side effects
Risks and risk factors
  • Sulfa medicine allergy
    • Allergy to sulfonamides such as Septra or Bactrim
  • Lower blood cell counts
  • Heat stroke and less sweating
    • Under age 18
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Higher blood acid
    • Diarrhea
    • Kidney disease
    • Severe COPD or lung disease
  • Withdrawal seizures
See more detailed risks and warnings
  • Changes in mood and suicidal thoughts and behaviors
  • Serious skin problems
  • Serious allergic reactions
  • Low sodium levels
  • Changes in alertness
    • Higher doses of Aptiom (eslicarbazepine)
  • Risk of increased seizures
See more detailed risks and warnings