Compare Zonegran vs. Banzel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zonegran (zonisamide)

Prescription only

Banzel (rufinamide)

Prescription only
Controls partial seizures.

Zonegran (zonisamide) is used with other medicines to help control partial seizures. It can't be used by itself.

Added to other medicines to control seizures caused by Lennox-Gastaut syndrome.

Banzel (rufinamide) is safe for children as young as 1 year old to control seizures caused by Lennox-Gastaut syndrome, but it cannot be taken by itself.

Upsides
  • Available in generic.
  • Can be given once a day, so it's easier to remember.
  • You can take Zonegran (zonisamide) with or without food.
  • Banzel (rufinamide) works well to control seizures when used with your other seizure medicines.
  • If you have trouble swallowing, Banzel (rufinamide) is available in liquid and tablets can be crushed or cut into smaller pieces.
Downsides
  • Zonegran (zonisamide) has to be used with other medicines to help control your seizures. It's not used by itself.
  • Zonegran (zonisamide) is only approved in people age 16 or older.
  • Zonegran (zonisamide) can cause kidney stones; so you have to make sure you drink plenty of liquids.
  • Zonegran (zonisamide) can weaken your bones. Talk to your doctor about how to keep your bones strong.
  • Other medicines used to control seizures can interact with Zonegran (zonisamide), so your doctor might have to change the dosing of your medications.
  • Banzel (rufinamide) has to be taken with other medicines to control seizures.
  • Banzel (rufinamide) is for seizures caused by a very specific condition, Lennox-Gastaut syndrome.
  • The dose of Banzel (rufinamide) may need to be adjusted frequently. You have to stick to the schedule from your doctor on how much and when to take it.
  • You have to talk to your doctor if you're interested in stopping Banzel (rufinamide). Stopping Banzel (rufinamide) suddenly can make your seizures worse.
  • Some people may be allergic to Banzel (rufinamide).
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Used for
  • Lennox-Gastaut syndrome
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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Side effects
34possible side effects
  • Sleepiness
    17%
  • Loss of appetite
    13%
  • Dizziness
    13%
  • Headache
    10%
  • Nausea
    9%
  • Agitation or Irritability
    9%
  • Fatigue
    8%
  • Tiredness
    7%
  • Stomach pain
    6%
  • Difficulty controlling movements
    6%
  • Confusion
    6%
  • Difficulty with concentration
    6%
  • Difficulty with memory
    6%
  • Depression
    6%
  • Trouble sleeping
    6%
  • Double vision
    6%
  • Diarrhea
    5%
  • Speech difficulties
    5%
  • Flu
    4%
  • Difficulty controlling eye movements
    4%
  • Prickling and tingling sensation
    4%
  • Mental slowing
    4%
  • Upset stomach
    3%
  • Weight loss
    3%
  • Anxiety
    3%
  • Skin rash
    3%
  • Constipation
    2%
  • Dry mouth
    2%
  • Bruising
    2%
  • Nervousness
    2%
  • Schizophrenia-like behavior
    2%
  • Difficulties in verbal expression
    2%
  • Stuffy nose
    2%
  • Changes in taste
    2%
See more detailed side effects
18possible side effects
  • Headache
    27%
  • Dizziness
    19%
  • Fatigue
    16%
  • Nausea
    12%
  • Sleepiness
    11%
  • Double vision
    9%
  • Tremors
    6%
  • Difficulty controlling eyes
    6%
  • Blurry vision
    6%
  • Vomiting
    5%
  • Movement coordination problems
    4%
  • Upper abdominal pain
    3%
  • Anxiety
    3%
  • Constipation
    3%
  • Indigestion
    3%
  • Back pain
    3%
  • Difficulty walking
    3%
  • Balance problems
    3%
See more detailed side effects
Risks and risk factors
  • Sulfa medicine allergy
    • Allergy to sulfonamides such as Septra or Bactrim
  • Lower blood cell counts
  • Heat stroke and less sweating
    • Under age 18
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Higher blood acid
    • Diarrhea
    • Kidney disease
    • Severe COPD or lung disease
  • Withdrawal seizures
See more detailed risks and warnings
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Sleepiness and movement problems
  • Heart problems
    • Familial short QT syndrome
  • Allergic reactions
    • Children under 12 years of age
  • Withdrawal seizures
    • Stopping Banzel (rufinamide) suddenly
See more detailed risks and warnings