Compare Zyprexa vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zyprexa (olanzapine)

Prescription only

Invega (paliperidone)

Prescription only
Helps control your thoughts and mood.

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.

3.7/ 5 average rating with 68 reviewsforZyprexa
Helps control your thoughts and mood.

Invega (paliperidone) relieves psychotic symptoms and improves mood.

3.1/ 5 average rating with 34 reviewsforInvega
Upsides
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
  • Won't make you as sleepy as other antipsychotic medicines.
  • If you have heart or kidney problems, this may be a better option than other antipsychotic medicines.
  • The pill and injection form allows for flexible dosing schedule.
Downsides
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
  • Side-effects of weight gain and hormonal imbalance may be intolerable for younger patients.
  • Frequent blood tests are sometimes required to check how the medicine is affecting your body.
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Injection
Price
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Reviews
68 reviews so far
41%
saidit'sworth it
51%
saiditworked well
51%
saidit'sa big hassle

Have you used Zyprexa (olanzapine)?

Leave a review
34 reviews so far
29%
saidit'sworth it
32%
saiditworked well
35%
saidit'sa big hassle

Have you used Invega (paliperidone)?

Leave a review
Side effects
9possible side effects
  • Drowsiness
    48%
  • Weight gain
    28%
  • Increased appetite
    28%
  • Headache
    17%
  • Fatigue
    14%
  • Dizziness
    7%
  • Dry Mouth
    7%
  • Abdominal pain
    6%
  • Pain in extremity
    5%
See more detailed side effects
16possible side effects
  • Difficulty controlling movements
    12%
  • Drowsiness
    8%
  • Indigestion
    6%
  • Inability to be still
    6%
  • Nausea
    5%
  • Constipation
    4%
  • Weight gain
    4%
  • Abdominal discomfort
    3%
  • Common cold
    3%
  • Back pain
    3%
  • Fast heartbeat
    2%
  • Stomach upset
    2%
  • Upper respiratory tract infection
    2%
  • Decreased appetite
    2%
  • Increased appetite
    2%
  • Changes in speech
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Blood disorders
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar, high cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
  • Higher blood sugar and cholesterol and weight gain
    • Diabetes
    • High cholesterol
  • Difficulty concentrating
    • Alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
See more detailed risks and warnings