Compare Zyprexa vs. Saphris
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Helps control your thoughts and mood.
Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.
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3.7/ 5 average rating with 68 reviewsforZyprexa
Treats bipolar disorder and schizophrenia.
While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.
Upsides
- Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
- Less likely to cause heart problems than other antipsychotics.
- Less likely to cause movement problems compared to older antipsychotics.
- Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
- You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
- Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
- More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
- Might make you more sleepy than some antipsychotics.
- Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
- You may need routine blood tests to check how the medicine is affecting your body..
- Saphris (asenapine) is only available as a brand name.
- Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
- You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Used for
Dosage forms
- Pill
- Dissolving tablet
- Injection
- Dissolving pill
Price
Lowest price
$641.59
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$604.75
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Reviews
68 reviews so far
41%
saidit'sworth it
51%
saiditworked well
51%
saidit'sa big hassle
Have you used Zyprexa (olanzapine)?
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Side effects
9possible side effects
- Drowsiness48%
- Weight gain28%
- Increased appetite28%
- Headache17%
- Fatigue14%
- Dizziness7%
- Dry Mouth7%
- Abdominal pain6%
- Pain in extremity5%
10possible side effects
- Sleepiness22%
- Trouble sleeping10%
- Difficulty controlling movements6%
- Numbness in the mouth5%
- Fatigue4%
- Dizziness4%
- Indigestion3%
- Swelling in the arms and legs3%
- Weight gain3%
- High blood pressure3%
Risks and risk factors
- Increased risk of death
- Elderly patients with dementia
- Blood disorders
- Neuroleptic malignant syndrome
- Heart problems
- History of heart problems
- Drug interactions
- Shaking and restlessness
- Higher blood sugar, high cholesterol, and weight gain
- People with diabetes
- People with high cholesterol
- Higher risk of death
- People age 65 or older with dementia and psychosis
- Neuroleptic malignant syndrome
- Taking antipsychotic medications
- Difficulty controlling movements
- Weight gain and diabetes
- Changes in blood pressure and fainting
- High blood pressure
- History of heart disease
- Higher risk of infection