Compare Zyrtec D vs. Advil Cold And Sinus
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Relieves congestion and allergy symptoms.
Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.
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3.7/ 5 average rating with 927 reviewsforZyrtec D
Relieves sinus pain and congestion.
Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a good combination medicine to relieve pain and congestion, but it's more medicine than you need if you only have one symptom.
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3.6/ 5 average rating with 1464 reviewsforAdvil Cold And Sinus
Upsides
- The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
- The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
- The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
- Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
- It's available without a prescription, unlike other strong allergy medicines.
- Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) is a combination medicine that relieves cold symptoms. It's good to use if you have congestion, sore throat, headache, or fever.
- Ibuprofen (a pain reliever) is more effective than acetaminophen at lowering fever and relieving sinus pain.
- Pseudoephedrine (a decongestant) clears nose congestion to help you breathe better.
Downsides
- You can have more side effects when using combination pills than when using single-ingredient medications.
- The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
- The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
- You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
- Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
- Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
- If you don't need both of the medications in this combination, you'd be taking extra medicine and can have extra side effects for no reason.
- The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
- It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
- Pseudoephedrine, the decongestant in Advil Cold And Sinus (Ibuprofen / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
Used for
Dosage forms
- Extended release
- Pill
No pricing information available
No pricing information available
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Reviews
927 reviews so far
75%
saidit'sworth it
43%
saiditworked well
9%
saidit'sa big hassle
Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?
Leave a review1464 reviews so far
75%
saidit'sworth it
34%
saiditworked well
6%
saidit'sa big hassle
Have you used Advil Cold And Sinus (Ibuprofen / Pseudoephedrine)?
Leave a reviewSide effects
The Zyrtec D (Cetirizine / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
The Advil Cold And Sinus (Ibuprofen / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- High blood pressure
- History of high blood pressure
- Heart problems
- History of heart problems
- Age 65 or older
- Seizure
- History of seizure
- Harm to fetus
- Women of childbearing age
- Taking the wrong medication
- Increased side effects
- Age 65 years or older
- Driving impairment
- Taking with alcohol
- Taking other medicines that make you less alert
- Overdosage
- Current kidney disease
- Current liver disease
- Stomach bleeding
- History of stomach bleeding or ulcers
- Age 60 years or older
- Taking aspirin, NSAIDs, or blood thinners
- Drinking more than 3 alcoholic beverages a day
- Harm to fetus
- Women of childbearing age
- High blood pressure
- History of high blood pressure
- Lower kidney function
- Kidney disease
- Heart failure
- Liver disease
- Taking high blood pressure medications
- Age 65 years or older
- Heart attack or stroke
- History of heart problems
- Age 65 years or older
- Taking with aspirin