Compare Zyrtec vs. Astepro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zyrtec (Cetirizine)

Prescription or OTC

Astepro (azelastine)

Prescription only
Treats allergy symptoms.

Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Relieves nasal allergy symptoms.

Astepro (azelastine) is an antihistamine nasal spray that can help with allergy or nasal symptoms.

Upsides
  • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (Cetirizine) is available over the counter without a prescription.
  • It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It's okay to take with most other medications because it has few drug interactions.
  • Most people don't get any side effects from Zyrtec (Cetirizine).
  • Astepro (azelastine) is good for relieving nasal symptoms during allergy season.
  • Since Astepro (azelastine) goes in the nose, it's unlikely you'll get side effects anywhere else in your body.
  • Astepro (azelastine) works faster than steroid nasal sprays and can be used as needed.
  • People usually tolerate Astepro (azelastine) well since there are few side effects.
Downsides
  • Although it works fast, its effectiveness wears off for some people over time.
  • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
  • Astepro (azelastine) has 200 sprays, but no counter to help keep track of sprays.
  • It can cause a bitter taste in your mouth.
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Used for
Dosage forms
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
  • Nasal spray
No pricing information available
No pricing information available
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Reviews
1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

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Side effects
The Zyrtec (Cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Bitter Taste
    8%
  • Nose discomfort
    4%
  • Nosebleeds
    2%
  • Headache
    2%
  • Fatigue
    2%
See more detailed side effects
Risks and risk factors
  • Taking the wrong medication
  • Increased side effects
    • Age 65 or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Overdosage
    • Current kidney disease
    • Current liver disease
See more detailed risks and warnings
  • Difficulty concentrating
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings