Compare Zyrtec vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats allergy symptoms.

Zyrtec (cetirizine) can help you with some allergy symptoms without making you very drowsy.

3.8/ 5 average rating with 1232 reviewsforZyrtec
Relieves cold and flu symptoms, and helps you sleep.

Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

3.8/ 5 average rating with 1188 reviewsforNyquil Cold And Flu
Upsides
  • Zyrtec (cetirizine) works to treat sneezing and runny nose, and causes less sedation compared to Benadryl.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (cetirizine) is available over the counter without a prescription. It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide relief of allergy symptoms for both kids and adults.
  • Zyrtec (cetirizine) has few drug interactions with other medicines.
  • Most people don't get any side effects from Zyrtec (cetirizine).
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides
  • Although it works fast, Zyrtec (cetirizine)'s effectiveness wears off for some people over time.
  • Zyrtec (cetirizine) can make you a little more sleepy compared to Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl (diphenhydramine), are more effective for them than Zyrtec (cetirizine).
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
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Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
1232 reviews so far
76%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

Have you used Zyrtec (cetirizine)?

Leave a review
1188 reviews so far
83%
saidit'sworth it
42%
saiditworked well
7%
saidit'sa big hassle

Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?

Leave a review
Side effects
The Zyrtec (cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased side effects in the elderly
    • Age 65 or older
  • Impaired alertness
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • History of liver or kidney conditions
    • History of liver or kidney disease
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Driving impairment
    • Taking with alcohol
    • Taking with other medicines that make you less alert
  • Antihistamine side effects
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
See more detailed risks and warnings