Compare Zyvox vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Zyvox (linezolid)

Prescription only
Treats bacterial infections.

Zyvox (linezolid) is good first-choice treatment for serious infections caused by gram positive bacteria.

Topical treatment for acne.

Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.

3.5/ 5 average rating with 115 reviewsforCleocin
  • Zyvox (linezolid) is effective at treating serious infections caused by certain types of bacteria.
  • Zyvox (linezolid) can be taken orally in liquid form or injected if you have trouble swallowing pills.
  • Available in generic.
  • Topical form treats acne.
  • Available in different oral forms: tablet, capsule, and suspension.
  • Available in forms to treat skin infections and vaginal infections.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
  • Zyvox (linezolid) can cause dangerously high blood pressures when combined with certain depression medications or excessive amounts of cheese or alcohol.
  • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
  • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
  • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
  • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
  • If you're taking the topical form, it can cause sensitivity and irritation.
Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
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115 reviews so far
saidit'sworth it
saiditworked well
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Side effects
9possible side effects
  • Diarrhea
  • Nausea
  • Headache
  • Vomiting
  • Dizziness
  • Rash
  • Anemia
  • Fungal infection of the mouth
  • Abnormal liver function
See more detailed side effects
The Cleocin T (Clindamycin Phosphate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Blood and bone marrow problems
    • Taking Zyvox (linezolid) for longer than 2 weeks
    • Existing bone marrow disease
    • Use of other medicines that affect the bone marrow suppression
    • Chronic infection
    • Use of other antibiotic therapies
  • Nerve and eye damage
  • Serotonin syndrome
    • Taking drugs for depression, migraines, or pain
  • Infectious diarrhea
    • Taking Zyvox (linezolid) for a long time
  • Acid buildup in the blood (lactic acidosis)
  • Low blood sugar
    • Diabetes
    • Using insulin or other diabetic medications
See more detailed risks and warnings
  • Diarrhea
  • Liver damage
    • History of liver disease
  • Rash
See more detailed risks and warnings