Compare Zyvox vs. daptomycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Zyvox (linezolid)

Prescription only

Cubicin (daptomycin)

Prescription only
Treats bacterial infections.

Zyvox (linezolid) is good first-choice treatment for serious infections caused by gram positive bacteria.

Treats bacterial infections.

Cubicin (daptomycin) is an antibiotic that's usually only given in the hospital for serious infections. It can be given at home, but you will have to be taught how to inject it correctly.

Upsides
  • Zyvox (linezolid) is effective at treating serious infections caused by certain types of bacteria.
  • Zyvox (linezolid) can be taken orally in liquid form or injected if you have trouble swallowing pills.
  • Cubicin (daptomycin) is good at treating severe and complicated bacterial infections.
  • It is able to kill bacteria that have resistance to other antibiotics.
  • Most people who take Cubicin (daptomycin) have few side effects.
  • You usually only need to take it once a day.
Downsides
  • Zyvox (linezolid) can cause dangerously high blood pressures when combined with certain depression medications or excessive amounts of cheese or alcohol.
  • Cubicin (daptomycin) is usually only given for extremely serious infections that haven't responded to other antibiotics.
  • Cubicin (daptomycin) can cause muscle aches and weakness, which can lead to kidney problems.
  • You might need to have more blood tests done while taking Cubicin (daptomycin).
  • Like most antibiotics, it is common to have diarrhea when taking this medicine.
  • While Cubicin (daptomycin) is generic, it is usually very expensive.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Injection
Price
No pricing information available
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Reviews
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Side effects
9possible side effects
  • Diarrhea
    8%
  • Nausea
    7%
  • Headache
    6%
  • Vomiting
    4%
  • Dizziness
    2%
  • Rash
    2%
  • Anemia
    2%
  • Fungal infection of the mouth
    2%
  • Abnormal liver function
    2%
See more detailed side effects
9possible side effects
  • Diarrhea
    5%
  • Headache
    5%
  • Rash
    4%
  • Abnormal liver tests
    3%
  • Muscle damage
    3%
  • Dizziness
    2%
  • Urinary tract infection
    2%
  • Low blood pressure
    2%
  • Shortness of breath
    2%
See more detailed side effects
Risks and risk factors
  • Blood and bone marrow problems
    • Taking Zyvox (linezolid) for longer than 2 weeks
    • Existing bone marrow disease
    • Use of other medicines that affect the bone marrow suppression
    • Chronic infection
    • Use of other antibiotic therapies
  • Nerve and eye damage
  • Serotonin syndrome
    • Taking drugs for depression, migraines, or pain
  • Infectious diarrhea
    • Taking Zyvox (linezolid) for a long time
  • Acid buildup in the blood (lactic acidosis)
  • Low blood sugar
    • Diabetes
    • Using insulin or other diabetic medications
See more detailed risks and warnings
  • Allergic reaction
    • Allergy to antibiotics
  • Muscle pain & kidney damage
    • History of kidney problems
    • Taking statins to lower cholesterol
  • Pneumonia
    • Taking Cubicin (daptomycin) for at least 2 to 4 weeks
  • Nerve damage
  • Diarrhea
See more detailed risks and warnings