Actoplus Met

(pioglitazone / metformin)

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Lowers blood sugar.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Actoplus Met (pioglitazone / metformin) is a single-pill combination of two first-choice anti-diabetic medicines, but may cause some undesireable side effects.

Lowest price near you
  • Price before coupon
    $410.95
  • Lowest price with coupon
    $323.71
  • Savings
    21%
Quick facts about Actoplus
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pioglitazone / metformin)

Upsides

  • Lowers A1c (average blood sugar) levels by 1%.
  • Easily taken by mouth as a pill.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
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What to expect from Actoplus, on one page

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Downsides

  • Can take several weeks to see full effect on your blood sugars.
  • Can cause stomach upset or weight gain.
  • Can cause fluid build up in the ankles or lungs.
  • Not a good choice if you have history of heart failure or bladder cancer.
  • Increases the risk of of bone fractures or poor kidney function.
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What to expect from Actoplus, on one page

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How it works

Actoplus Met (pioglitazone / metformin) is a combination anti-diabetic medicine, which enhances your body's sensitivy to insulin and lowers production of sugar.

Quick facts about Actoplus
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pioglitazone / metformin)

Dosage forms

  • Pill
  • Extended release
Tried Actoplus? Write a review!

Prices and coupons

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What to expect when you take Actoplus Met (pioglitazone / metformin) for Type 2 diabetes

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Diarrhea
  • Headache
  • Colds and flu
  • Low blood sugar
  • Swelling
  • Heart failure
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Side effect rates for Actoplus Met (pioglitazone / metformin)

From 328 clinical trials of Actoplus when taken for type 2 diabetes (30mg)
  • Colds and flu
    12%12%
  • Swelling
    6%6%
    3%3%
  • Headache
    6%6%
    3%3%
  • Swelling
    6%6%
  • Headache
    6%6%
  • Weight gain
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Actoplus.

Actoplus Met (pioglitazone / metformin)
Placebo

People taking Actoplus felt side effect more

People taking Actoplus felt side effect less

No difference

Risks and Warnings for Actoplus Met (pioglitazone / metformin)

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    • Higher risk if:
    • Heart failure

    Pioglitazone, one of the medicines in Actoplus Met (pioglitazone / metformin), can cause fluid buildup that can lead to or worsen heart failure. If you have advanced heart failure, talk to your doctor since you shouldn't use Actoplus Met (pioglitazone / metformin). Your doctor will check your heart regularly while you're taking Actoplus Met (pioglitazone / metformin).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Actoplus Met (pioglitazone / metformin) questions for

Frequently Asked Questions

This medication treats type 2 diabetes in adults.

Who is this drug for?

This medication treats type 2 diabetes in adults.

Common concerns from people taking Actoplus Met (pioglitazone / metformin)

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Food
  • Take with food to reduce stomach upset.
Kidneys and liver
  • If you've had liver problems or damage in the past, talk to your doctor before starting Actoplus Met (pioglitazone / metformin), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
  • Increases the risk of of bone fractures or poor kidney function.
Weight
  • Can cause diarrhea, weight gain and cold-like symptoms.
  • Can cause stomach upset or weight gain.