Humira

(adalimumab)

3.6/ 5 average rating with 182 reviewsforHumira
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Calms down the immune system.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

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    $4846.48
Quick facts about Humira
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
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What to expect from Humira, on one page

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People’s experience with Humira

182reviews so far. What do you think?

Downsides

  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
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What to expect from Humira, on one page

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How it works

Humira (adalimumab) is a TNF blocker which stops inflammation.

Quick facts about Humira
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Injection
People’s experience with Humira

182reviews so far. What do you think?

Prices and coupons

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What to expect when you take Humira (adalimumab) for Autoimmune diseases

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Upper airway infection
  • Headache
  • Rash
  • Sinus infections
  • Nausea
  • Injection site reactions
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Side effect rates for Humira (adalimumab)

From 1395 clinical trials of Humira when taken for rheumatoid arthritis (40 mg every other week)
  • Upper airway infection
    17%17%
    13%13%
  • Headache
    12%12%
    8%8%
  • Rash
    12%12%
    6%6%
  • Sinus infection
    11%11%
    9%9%
  • Nausea
    9%9%
    8%8%
  • Injection site reactions
    8%8%
    1%1%
  • Urinary tract infection
    8%8%
    5%5%
  • Flu syndrome
    7%7%
    6%6%
  • Stomach pain
    7%7%
    4%4%
  • High cholesterol
    7%7%
    5%5%
  • Back pain
    6%6%
    4%4%
  • Blood in urine
    5%5%
    4%4%
  • Abnormal liver tests
    5%5%
    3%3%
  • High blood pressure
    5%5%
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Humira.

Humira (adalimumab)
Placebo

People taking Humira felt side effect more

People taking Humira felt side effect less

No difference

Risks and Warnings for Humira (adalimumab)

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    • Higher risk if:
    • Taking other immunosuppressant medications such as Kineret or Orencia
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities

    Humira (adalimumab) can increase your risk of serious or life-threatening infections. In some cases, existing inactive infections can be reactivated such as tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Humira (adalimumab). If you develop symptoms of cough, fever, chills, muscle aches, fatigue, dark urine, yellowing of skin/eyes, loss of appetite, vomiting, change in stool color, stomach discomfort, or skin rash, tell your doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Humira (adalimumab) questions for

Frequently Asked Questions

This medication treats active ankylosing spondylitis in adults.

Who is this drug for?

This medication treats active ankylosing spondylitis in adults.

Common concerns from people taking Humira (adalimumab)

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Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Humira
BProbably safe
Price
  • Worth it
    Some hassle
    Reviewed Humiraon 2/16/2017the cost of the medication is really the main issue
    65
    Woman
    Psoriatic arthritis
Alcohol
  • Not worth it
    Big hassle
    Reviewed Humiraon 10/7/2016Don't drink alcohol the day before for less pain. Always had bruising and muscle pain for day after injection. Along with headache.
    22
    Man
    Crohn's disease (moderate to severe)
Pain
  • Worth it
    Some hassle
    Reviewed Humiraon 2/13/2018Medication itself is painful, not the needle. Letting it warm to room temperature and icing injection site before use helps.
    21
    Woman
    Two years or more
    Would rather not say
  • Not sure
    Low hassle
    Reviewed Humiraon 3/26/2017Find the shot painful, very painful. Does help to let it get to room temperature, but the pain is still more than I expect., stings like hell!
    70
    Man
    A few months
    Crohn's disease (moderate to severe)
  • Worth it
    Low hassle
    Reviewed Humiraon 3/11/2017This drug gave me my life back. I had gotten to the wheelchair stage with back pain and was retired early on health grounds. Once the Humira kicked in I didn't even need a stick to walk anymore, so retirement is OK! My tip is that, if you were put on other drugs to treat back pain before going on Humira, you might want to consider coming off them once the Humira works. Oh, and I'm terrified of needles, but the new formulation feels completely painless (1hr warm up)
    57
    Man
    Two years or more
    Ankylosing spondylitis