Alka-Seltzer Plus Cold

(Aspirin / Chlorpheniramine / Phenylephrine)

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Relieves cold symptoms.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.

Quick facts about Alka-Seltzer Plus Cold
  • Drug class: Respiratory
  • Rx status: Over-the-counter
  • Generic status: No lower cost generic available

Upsides

  • Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • It's available in a variety of flavors.
Tried Alka-Seltzer Plus Cold? Write a review!

Downsides

  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The aspirin in Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) interacts with many other drugs and health conditions.
How it works

Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Aspirin relieves pain and reduces fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.

Quick facts about Alka-Seltzer Plus Cold
  • Drug class: Respiratory
  • Rx status: Over-the-counter
  • Generic status: No lower cost generic available
Tried Alka-Seltzer Plus Cold? Write a review!
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Side effect rates for Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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These are side effects of Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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    • Higher risk if:
    • History of stomach bleeding or ulcers
    • Age 60 years or older
    • Taking aspirin, NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day

    Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine) contains aspirin, which can cause serious problems including inflammation, bleeding, and ulcers in the stomach or intestines. The longer you take Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine), the higher the risk is. If you notice blood or a dark/black color in your stool, tell your doctor right away.

Common concerns from people taking Alka-Seltzer Plus Cold (Aspirin / Chlorpheniramine / Phenylephrine)

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Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Alka-Seltzer Plus Cold
NUnknown