Ambisome

(amphotericin B liposome)

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Treats fungal infections.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Effective treatment for severe and otherwise, deadly fungal infections.

Quick facts about Ambisome
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (amphotericin b liposome)

Upsides

  • This is a potentially life-saving medication for serious fungal infections.
  • May cause less side effects and harm to your kidneys compared to the conventional formulation of the drug and Abelcet.
  • Your doctor may be able to give you medicines to prevent or manage any reactions you may have to Ambisome (amphotericin B liposome).
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What to expect from Ambisome, on one page

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Downsides

  • Can only be given as an injection that runs over 1 to 2 hours.
  • Can only be given in a hospital or by trained home health care professional.
  • The entire treatment can range from 1 to 12 weeks, depending on the severity of your infection.
  • Has a lot of side effects like fever, chills, nausea, vomitting, and diarrhea. Your doctor may order regular blood tests to monitor your labs.
  • Your body may have an allergic reaction to the drug or the way it is administered.
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What to expect from Ambisome, on one page

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How it works

Ambisome (amphotericin B liposome) is an antifungal. It kills fungus by disrupting the fungal cell membrane.

Quick facts about Ambisome
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (amphotericin b liposome)

Used for

Dosage forms

  • Injection
Tried Ambisome? Write a review!

What to expect when you take Ambisome (amphotericin B liposome) for Fungal infection

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Injection related side effects
  • Nausea
  • Vomiting
  • Diarrhea
  • Kidney injury
  • Headache
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Side effect rates for Ambisome (amphotericin B liposome)

From 687 clinical trials of Ambisome when taken for fever with low white blood counts
  • Chills
    48%48%
    76%76%
  • Low potassium
    43%43%
    51%51%
  • Nausea
    40%40%
    39%39%
  • Vomiting
    32%32%
    44%44%
  • Diarrhea
    30%30%
    27%27%
  • Rash
    25%25%
    24%24%
  • HIgh glucose
    23%23%
    28%28%
  • Shortness of breath
    23%23%
    28%28%
  • Liver labs (alkaline phosphatase) increased
    22%22%
    19%19%
  • Abnormal kidney function tests (creatinine)
    22%22%
    42%42%
  • Abnormal kidney function tests (blood urea nitrogen)
    21%21%
    31%31%
  • Abdominal pain
    20%20%
    22%22%
  • Low magnesium
    20%20%
    26%26%
  • Headache
    20%20%
    21%21%
  • Blood product transfusion reaction
    18%18%
    19%19%
  • Abnormal liver function (bilirubinemia)
    18%18%
    19%19%
  • Low calcium
    18%18%
    21%21%
  • Cough increased
    18%18%
    22%22%
  • Lung disorder
    18%18%
    17%17%
  • Insomnia
    17%17%
    14%14%
  • Abnormal liver enzymes (ALT)
    15%15%
    14%14%
  • Swelling of the hands and feet
    15%15%
    17%17%
  • Sudden nose bleeds
    15%15%
    20%20%
  • Pain
    14%14%
    13%13%
  • Life-threatening infection
    14%14%
    11%11%
  • Low blood pressure
    14%14%
    22%22%
  • Fluid retention
    14%14%
    15%15%
  • Anxiety
    14%14%
    11%11%
  • Blood in urine
    14%14%
    14%14%
  • Weakness
    13%13%
    11%11%
  • Fast heart rate
    13%13%
    21%21%
  • Abnormal liver enzymes (ALT)
    13%13%
    13%13%
  • Fluid in the lungs
    13%13%
    10%10%
  • Back pain
    12%12%
    7%7%
  • Chest pain
    12%12%
    12%12%
  • Low fluid volume
    12%12%
    15%15%
  • Infection
    11%11%
    9%9%
  • Confusion
    11%11%
    13%13%
  • Runny nose
    11%11%
    11%11%
  • Itching
    11%11%
    10%10%
  • Bleeding in the stomach
    9%9%
    11%11%
  • High blood pressure
    8%8%
    16%16%
  • Low oxygen in the lungs
    8%8%
    15%15%
  • Sweating
    7%7%
    11%11%
  • High sodium
    4%4%
    11%11%
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Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Ambisome.

Ambisome (amphotericin B liposome)
Placebo

People taking Ambisome felt side effect more

People taking Ambisome felt side effect less

No difference

Risks and Warnings for Ambisome (amphotericin B liposome)

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  • Ambisome (amphotericin B liposome) can cause a sever allergic reaction. If you develop swelling in the face and difficulty breathing, call for emergency help right away.

Common concerns from people taking Ambisome (amphotericin B liposome)

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Kidneys and liver
  • Ambisome (amphotericin B liposome) can cause injuries to your kidneys. Your doctor will order blood tests for you to monitor your kidney health. If you notice pain or blood upon urination, or have difficulty with urination, notify your doctor immediately.
  • You doctor may order regular blood tests to monitor your blood sugar, potassium, magnesium, and kidney function.
  • May cause less side effects and harm to your kidneys compared to the conventional formulation of the drug and Abelcet.
Sleep
  • Can caue rash, chills, headache, tiredness, and nausea with the first doses, but should go away over time.