Asendin

(amoxapine)

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Stabilizes your mood.

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Our bottom line

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

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    $32.88
Quick facts about amoxapine
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (amoxapine)

Upsides

  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
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Downsides

  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
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What to expect from amoxapine, on one page

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How it works

Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.

Quick facts about amoxapine
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (amoxapine)

Used for

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Asendin (amoxapine) for Depression

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Changes in movement
  • Increased risk of suicide
  • Insomnia
  • Drowsiness
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Side effect rates for Asendin (amoxapine)

  • Drowsiness or fatigue
    14%14%
  • Dry mouth
    14%14%
  • Constipation
    12%12%
  • Vision changes
    7%7%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of amoxapine.

Asendin (amoxapine)
Placebo

People taking amoxapine felt side effect more

People taking amoxapine felt side effect less

No difference

Risks and Warnings for Asendin (amoxapine)

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    • Higher risk if:
    • People under age 24

    Taking Asendin (amoxapine) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Asendin (amoxapine), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Asendin (amoxapine) questions for

Frequently Asked Questions

This medication treats depression.

Who is this drug for?

This medication treats depression.

Common concerns from people taking Asendin (amoxapine)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for amoxapine
CWeigh risks vs. benefits
Food
  • Take Asendin (amoxapine) with food to avoid stomach upset.
Sleep
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.