Angeliq

(drospirenone / estradiol)

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Relieves hot flashes and vaginal dryness due to menopause.

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Our bottom line

Angeliq (drospirenone / estradiol) helps relieve menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.

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    $184.61
Quick facts about Angeliq
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Angeliq (drospirenone / estradiol) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Useful for women who experience moderate to severe symptoms of menopause.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
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What to expect from Angeliq, on one page

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Downsides

  • There are more possible side effects since it exposes your whole body to two hormones.
  • Angeliq (drospirenone / estradiol) can't be used by women who have had their uterus removed.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Compared to other estrogen-progestin combination medicines, you might be more likely to have blood clots with Angeliq (drospirenone / estradiol).
  • Angeliq (drospirenone / estradiol) might increase your potassium, which can be dangerous if you're taking other medicines that do the same.
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What to expect from Angeliq, on one page

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How it works

Angeliq (drospirenone / estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Drospirenone (a progestin) protects the uterus from damage.

Quick facts about Angeliq
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Angeliq (drospirenone / estradiol) for Vaginal dryness and inflammation

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
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  • Possible side effects
  • Stomach pain
  • Headache
  • Yeast infections
  • Breast pain
  • Nausea
  • Diarrhea
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Side effect rates for Angeliq (drospirenone / estradiol)

From 363 clinical trials of Angeliq when taken for menopausal symptoms (0.25/0.5 mg)
  • Stomach pain
    6%6%
    3%3%
  • Headache
    6%6%
    5%5%
  • Yeast infections
    6%6%
    1%1%
  • Breast pain
    3%3%
    1%1%
  • Nausea
    3%3%
    1%1%
  • Diarrhea
    2%2%
    1%1%
  • Swelling of arms and legs
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Angeliq.

Angeliq (drospirenone / estradiol)
Placebo

People taking Angeliq felt side effect more

People taking Angeliq felt side effect less

No difference

Risks and Warnings for Angeliq (drospirenone / estradiol)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Angeliq (drospirenone / estradiol) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Angeliq (drospirenone / estradiol) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Angeliq (drospirenone / estradiol)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Angeliq
XUnsafe