Saphris

(asenapine)

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Treats bipolar disorder and schizophrenia.

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Our bottom line

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

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  • Lowest price with coupon
    $604.75
Quick facts about Saphris
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
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What to expect from Saphris, on one page

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Downsides

  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
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What to expect from Saphris, on one page

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How it works

While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.

Quick facts about Saphris
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Dissolving pill
Tried Saphris? Write a review!

Prices and coupons

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What to expect when you take Saphris (asenapine) for Schizophrenia

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Weight gain
  • Diabetes
  • Changes in blood pressure
  • Higher risk of infection
  • Sleepiness
  • Numbness in the mouth
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Side effect rates for Saphris (asenapine)

From 324 clinical trials of Saphris when taken for bipolar disorder, adjunct (twice daily, 5 or 10 mg)
  • Sleepiness
    22%22%
    10%10%
  • Trouble sleeping
    10%10%
    8%8%
  • Difficulty controlling movements
    6%6%
    5%5%
  • Numbness in the mouth
    5%5%
  • Fatigue
    4%4%
    2%2%
  • Dizziness
    4%4%
    2%2%
  • Indigestion
    3%3%
    2%2%
  • Swelling in the arms and legs
    3%3%
    1%1%
  • Weight gain
    3%3%
  • High blood pressure
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Saphris.

Saphris (asenapine)
Placebo

People taking Saphris felt side effect more

People taking Saphris felt side effect less

No difference

Risks and Warnings for Saphris (asenapine)

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    • Higher risk if:
    • People age 65 or older with dementia and psychosis

    Older people who have dementia and psychosis have a higher risk of death if they take antipsychotic medicines like Saphris (asenapine). They shouldn't be given this medicine.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Saphris (asenapine)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Saphris
CWeigh risks vs. benefits
Weight
  • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.