Atripla

(efavirenz / emtricitabine / tenofovir)

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Treats HIV infection.

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Our bottom line

Atripla (efavirenz / emtricitabine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It is a second-line choice due to its high incidence of undesired side effects.

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Quick facts about Atripla
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Atripla (efavirenz / emtricitabine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Atripla (efavirenz / emtricitabine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • There are drug assistance programs available either through the government (AIDS Drug Assistance Program aka. ADAP) or through the drug manufacturer which can help with drug costs and co-pays.
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What to expect from Atripla, on one page

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Downsides

  • Atripla (efavirenz / emtricitabine / tenofovir) can increase your risk of depression, and should be used with caution you have a history of seizures or osteoporosis.
  • Women should avoid becoming pregnant while taking Atripla (efavirenz / emtricitabine / tenofovir) and for 12 weeks after stopping Atripla (efavirenz / emtricitabine / tenofovir).
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.
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What to expect from Atripla, on one page

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How it works

Atripla (efavirenz / emtricitabine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.

Quick facts about Atripla
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Atripla? Write a review!

Prices and coupons

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What to expect when you take Atripla (efavirenz / emtricitabine / tenofovir) for HIV treatment

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Rash
  • Dizziness
  • Fatigue
  • Nausea
  • Depression
  • Insomnia
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Side effect rates for Atripla (efavirenz / emtricitabine / tenofovir)

From 257 clinical trials of Atripla when taken for hiv treatment
  • Diarrhea
    9%9%
  • Nausea
    9%9%
  • Fatigue
    9%9%
  • Depression
    9%9%
  • Sinusitis
    8%8%
  • Upper respiratory tract infections
    8%8%
  • Dizziness
    8%8%
  • Rash Event
    7%7%
  • Headache
    6%6%
  • Nasopharyngitis
    5%5%
  • Anxiety
    5%5%
  • Insomnia
    5%5%
  • Vomiting
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Atripla.

Atripla (efavirenz / emtricitabine / tenofovir)
Placebo

People taking Atripla felt side effect more

People taking Atripla felt side effect less

No difference

Risks and Warnings for Atripla (efavirenz / emtricitabine / tenofovir)

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    • Higher risk if:
    • Liver disease
    • Women
    • Obesity

    Atripla (efavirenz / emtricitabine / tenofovir) can cause this rare but life-threatening condition. Symptoms include difficulty breathing, nausea, vomiting, right sided stomach pain, and dark urine . This is a medical emergency and you should get help right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Atripla (efavirenz / emtricitabine / tenofovir) questions for

Frequently Asked Questions

Atripla treats HIV-1 alone or in combination with other antiretroviral medications.

Who is this drug for?

Atripla treats HIV-1 alone or in combination with other antiretroviral medications.

Common concerns from people taking Atripla (efavirenz / emtricitabine / tenofovir)

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Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Atripla
DWeigh risks vs. benefits
Kidneys and liver
  • One of the medications in Atripla (efavirenz / emtricitabine / tenofovir) can cause kidney damage. This can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
  • Might be inconvenient if used in patients with poorly functioning kidneys because there is no way to adjust the dose of the individual drug components.