Lioresal

(baclofen)

3.5/ 5 average rating with 33 reviewsforbaclofen
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Relaxes your muscles.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

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Quick facts about baclofen
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (baclofen)

Upsides

  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
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What to expect from baclofen, on one page

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People’s experience with baclofen

33reviews so far. What do you think?

Downsides

  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
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How it works

Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.

Quick facts about baclofen
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (baclofen)

Used for

Dosage forms

  • Pill
People’s experience with baclofen

33reviews so far. What do you think?

Prices and coupons

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What to expect when you take Lioresal (baclofen) for Muscle spasticity

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  • First few hoursHours
    First few daysDays
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
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  • Possible side effects
  • Drowsiness
  • Urinary problems
  • Dizziness
  • Nausea
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Side effect rates for Lioresal (baclofen)

  • Drowsiness
    63%63%
    36%36%
0%
10%
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30%
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80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of baclofen.

Lioresal (baclofen)
Placebo

People taking baclofen felt side effect more

People taking baclofen felt side effect less

No difference

Risks and Warnings for Lioresal (baclofen)

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    • Higher risk if:
    • Stopping Lioresal (baclofen) too quickly

    If you've been taking Lioresal (baclofen) for a while, stopping it suddenly can be dangerous. People have had seizures and hallucinations. Talk to your doctor about stopping it slowly so this doesn't happen to you.

Pharmacist Q&A

Lioresal (baclofen) questions for

Frequently Asked Questions

This medication treat muscle spasms in adults with multiple sclerosis, spinal cord injuries, and other spinal cord diseases.

Who is this drug for?

This medication treat muscle spasms in adults with multiple sclerosis, spinal cord injuries, and other spinal cord diseases.

Common concerns from people taking Lioresal (baclofen)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for baclofen
CWeigh risks vs. benefits
Alcohol
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
Pain
  • Worth it
    Low hassle
    Reviewed baclofenon 9/27/2015Good for muscle aches from withdrawal but no other improvements from opiate withdrawal. Worked really well for muscle cramps and pain though. Not help with insomnia. I'm writing this review at 2:00am because I can't sleep.
    32
    Woman
    A couple weeks
    Withdrawal symptoms
Sleep
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Worth it
    Some hassle
    Reviewed baclofenon 11/24/2016Sleep issues? I thought I was just an insomniac. Turns out it is this med that causes it. Also, folks say it's hard to get off this med.
    36
    Woman
    Spasticity