Casodex

(bicalutamide)

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Helps treat metastatic prostate cancer.

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Our bottom line

Casodex (bicalutamide) treats later stages of prostate cancer in combination with another medication, but it can cause hot flashes.

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Quick facts about Casodex
  • Drug class: Cancer
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (bicalutamide)

Upsides

  • Available in a cheaper, generic version.
  • The pill can be adminstered at home instead of injected at an infusion clinic.
  • Safe for use even if you have kidney disease.
  • Less side-effects than other medicines that work similarly.
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What to expect from Casodex, on one page

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Downsides

  • Casodex (bicalutamide) doesn't control cancer as well as newer medicines that work similarly.
  • Casodex (bicalutamide) damages the lungs and liver so not a good option if you have pre-existing lung or liver disease.
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What to expect from Casodex, on one page

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How it works

Casodex (bicalutamide) is a nonsteroidal androgen receptor block. It blocks the stimulatory effect that androgen hormones like testosterone have on cancerous prostate cells.

Quick facts about Casodex
  • Drug class: Cancer
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (bicalutamide)

Dosage forms

  • Pill
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What to expect when you take Casodex (bicalutamide) for Prostate cancer

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  • First few hoursHours
    First few daysDays
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
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  • Possible side effects
  • General pain
  • Weakness
  • Stomach pain
  • Constipation
  • Nausea
  • Hot flashes
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Side effect rates for Casodex (bicalutamide)

From 401 clinical trials of Casodex when taken for prostate cancer
  • Hot flashes
    53%53%
  • General pain
    35%35%
  • Back pain
    25%25%
  • Weakness
    22%22%
  • Constipation
    22%22%
  • Pelvic pain
    21%21%
  • Infection
    18%18%
  • Nausea
    15%15%
  • Swelling in the limbs
    13%13%
  • Labored breathing
    13%13%
  • Diarrhea
    12%12%
  • Excessive urination at night
    12%12%
  • Blood in urine
    12%12%
  • Stomach pain
    11%11%
  • Anemia
    11%11%
  • Dizziness
    10%10%
  • Bone pain
    9%9%
  • Rash
    9%9%
  • Urinary Tract Infection
    9%9%
  • Male breasts
    9%9%
  • Chest pain
    8%8%
  • High blood pressure
    8%8%
  • Burning/tingling sensation
    8%8%
  • Increased cough
    8%8%
  • Inflammation of back of throat
    8%8%
  • Headache
    7%7%
  • Flu syndrome
    7%7%
  • Increase liver enzyme test
    7%7%
  • Indigestion
    7%7%
  • Weight loss
    7%7%
  • Muscle weakness
    7%7%
  • Difficulty sleeping
    7%7%
  • Impotence
    7%7%
  • Gas
    6%6%
  • Loss of appetite
    6%6%
  • Vomiting
    6%6%
  • High blood sugar
    6%6%
  • Inflammation of bronchial tubes
    6%6%
  • Sweating
    6%6%
  • Breast pain
    6%6%
  • Urinary frequency
    6%6%
  • Increase alkaline phosphatase
    5%5%
  • Weight gain
    5%5%
  • Joint inflammation
    5%5%
  • Anxiety
    5%5%
  • Urinary retention
    5%5%
  • Impaired urination
    5%5%
  • Fracture
    4%4%
  • Depression
    4%4%
  • Pneumonia
    4%4%
  • Stuffy nose
    4%4%
  • Urinary incontinence
    4%4%
0%
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Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Casodex.

Casodex (bicalutamide)
Placebo

People taking Casodex felt side effect more

People taking Casodex felt side effect less

No difference

Risks and Warnings for Casodex (bicalutamide)

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  • Casodex (bicalutamide) can damage your liver. This is more likely to happen within the first 3 to 4 months of treatment. Your doctor will draw your blood regularly to monitor your liver function. Talk to your doctor if you experience severe abdominal pain, dark urine, or pale stools.

Common concerns from people taking Casodex (bicalutamide)

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Food
  • Take Casodex (bicalutamide) at the same time each day, either in the morning or in the evening. It can be taken with or without food.
Kidneys and liver
  • Safe for use even if you have kidney disease.
Pain
  • Casodex (bicalutamide) causes enlargement of breast tissue in males, which causes pain and sensitivity. Talk to your doctor if you notice this occuring.